Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Krippl, P; Langsenlehner, U; Renner, W; Yazdani-Biuki, B; Wolf, G; Wascher, TC; Paulweber, B; Haas, J; Samonigg, H.
A common 936 C/T gene polymorphism of vascular endothelial growth factor is associated with decreased breast cancer risk.
Int J Cancer. 2003; 106(4):468-471
Doi: 10.1002/ijc.11238
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Krippl Peter
- Co-Autor*innen der Med Uni Graz
- Haas Josef
- Langsenlehner Uwe
- Renner Wilfried
- Samonigg Hellmut
- Wascher Thomas
- Yazdani-Biuki Babak
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- A common 936 C/T polymorphism in the gene for the vascular endothelial growth factor (VEGF) has been associated with VEGF plasma levels. In our case-control study, we investigated the role of this polymorphism for breast cancer risk. VEGF genotype was determined in 500 women with breast cancer and 500 sex- and age-matched healthy control subjects. Carriers of a 936T-allele were more frequent among controls (29.4%) than among patients (17.6%; p = 0.000014). The odds ratio for carriers of a 936T-allele for breast cancer was 0.51 (95% confidence interval 0.38-0.70). Additionally, VEGF plasma levels were determined in 21 nonsmoking post-menopausal controls; carriers of a 936T allele had significantly lower levels (median 23 pg/ml; range 6-50 pg/ml) than noncarriers (37; 21-387; p = 0.034). We conclude that carriers of a VEGF 936T-allele are at decreased risk for breast cancer, this, however, requiring further confirmation in a larger study.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Breast Neoplasms - epidemiology
- Case-Control Studies -
- DNA Mutational Analysis -
- DNA Primers - chemistry
- DNA, Neoplasm - genetics
- Endothelial Growth Factors - blood
- Female -
- Gene Expression Regulation, Neoplastic -
- Gene Frequency -
- Genotype -
- Humans -
- Intercellular Signaling Peptides and Proteins - blood
- Lymphokines - blood
- Middle Aged -
- Point Mutation -
- Polymerase Chain Reaction -
- Polymorphism, Genetic - genetics
- Risk Factors -
- Vascular Endothelial Growth Factor A -
- Vascular Endothelial Growth Factors -
- Find related publications in this database (Keywords)
- angiogenesis
- breast cancer
- epidemiology
- genetics