Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Mayer, B; Zitta, S; Greilberger, J; Holzer, H; Reibnegger, G; Hermetter, A; Oettl, K.
Effect of hemodialysis on the antioxidative properties of serum.
Biochim Biophys Acta. 2003; 1638(3):267-272
Doi: 10.1016/S0925-4439(03)00093-0
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- Führende Autor*innen der Med Uni Graz
- Öttl Karl
- Co-Autor*innen der Med Uni Graz
- Greilberger Joachim
- Holzer Herwig
- Reibnegger Gilbert
- Zitta Sabine
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- Abstract:
- In patients with chronic renal failure undergoing regular hemodialysis (HD), oxidative stress is involved in the development of dialysis-related pathologies. The aim of the study was to measure the effect of HD treatment on the general antioxidative status of serum with special consideration of the specific oxidizability of lipids and proteins. Indicators for the oxidative/antioxidative status of plasma were monitored at the beginning and at the end of a dialysis session on the arterial and venous side of the dialyzer. A decrease in the antioxidant status was accompanied by an increased oxidizability of proteins as well as lipids during HD treatment. During the first passage of the dialyzer, the lag time of lipid oxidation decreased from 114.0+/-19.8 to 81.5+/-18.9 min, the lag time of protein oxidation decreased from 105.0+/-24.6 to 72.9+/-21.3 min and the total antioxidative status decreased from 518+/-24 to 252+/-124 microM trolox equivalents. The carbonyl content of serum proteins was high in patients with end stage renal disease (ESRD) (3.9+/-1.1 vs. 0.9+/-0.1 nmol/mg in controls) but did not change significantly during dialysis procedure. Our data demonstrate that the susceptibility of serum lipids and proteins to oxidative modification is severely increased by HD treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Antioxidants - chemistry Antioxidants - metabolism
- Blood - metabolism
- Blood Chemical Analysis -
- Female -
- Humans -
- Kidney Failure, Chronic - blood Kidney Failure, Chronic - therapy
- Lipids - chemistry
- Male -
- Middle Aged -
- Monitoring, Physiologic -
- Oxidation-Reduction -
- Proteins - chemistry
- Renal Dialysis -
- Time Factors -
- Find related publications in this database (Keywords)
- hemodialysis
- end stage renal disease
- antioxidant
- free radical
- oxidative stress