Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Suneetha, LM; Singh, SS; Vani, M; Vardhini, D; Scollard, D; Archelos, JJ; Srinivasulu, M; Suneetha, S.
Mycobacterium leprae binds to a major human peripheral nerve glycoprotein myelin P zero (P0).
Neurochem Res. 2003; 28(9):1393-1399
Doi: 10.1023%2FA%3A1024904717612
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- Co-Autor*innen der Med Uni Graz
- Archelos-Garcia Juan-Jose
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- Abstract:
- We have previously shown that a major phosphorylated 25-kDa glycoprotein of the human peripheral nerve binds to Mycobacterium leprae. In the present study, we confirm that the 25-kDa glycoprotein of the human peripheral nerve is myelin P zero (P0) by immunoprecipitation and Western blot experiments using monoclonal antibodies to myelin P0. Immunohistochemical studies on human nerve using these antibodies to myelin P0 exhibited a strong immunoreactivity to the myelin and Schwann cells. Myelin P0 is a peripheral nerve specific protein; therefore it could likely be one of the key target molecules for M. leprae binding/internalization or even contact-dependent demyelination. This finding of M. leprae binding to myelin P0 adds to the present understanding on neural predilection of M. leprae.
- Find related publications in this database (using NLM MeSH Indexing)
- Antibodies, Monoclonal -
- Antibody Specificity -
- Bacterial Proteins - chemistry
- Blotting, Western - chemistry
- Chromatography, Affinity - chemistry
- Copper - chemistry
- Humans - chemistry
- Indicators and Reagents - chemistry
- Molecular Weight - chemistry
- Mycobacterium leprae - chemistry
- Myelin P0 Protein - chemistry
- Phosphorylation - chemistry
- Precipitation - chemistry
- Protein Binding - chemistry
- Find related publications in this database (Keywords)
- human peripheral nerve
- protein phosphorylation
- Mycobacterium leprae
- myelin P-0