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Selected Publication:
Görlach, G; Sroka, J; Heidt, M; Knez, I; Sablotzki, A; Schönburg, M; Akintürk, H; Roth, P; Wozniak, G; Vogt, PR.
Intracellular adhesion molecule-1 in patients developing pulmonary insufficiency after cardiopulmonary bypass.
Thorac Cardiovasc Surg. 2003; 51(3):138-141
Doi: 10.1055/s-2003-40314
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- Co-authors Med Uni Graz
- Knez Igor
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- Abstract:
- Cardiopulmonary bypass activates adhesion molecules, which are associated with systemic inflammation and organ dysfunction. The intracellular adhesion molecule-1 (ICAM-1) has been evaluated in patients presenting pulmonary dysfunction after cardiac surgery. Postoperative serum levels of the ICAM-1 were measured in 40 patients who underwent isolated coronary artery bypass grafting, in 28 with uneventful postoperative recovery (70 %) (Group 1), and in 12 (30 %) with postoperative respiratory insufficiency (Group 2), defined by the need for prolonged (> 24 hours) mechanical ventilation using a fractional oxygen concentration of > 40 %. Patients in group 1 were ventilated for 12.21 +/- 4.86 hours and those in group 2 for 92.91 +/- 48.14 hours (p < 0.001). ICAM-1 decreased from 145.98 +/- 73.40 ng/ml to 81.15 +/- 114.82 ng/ml in group 1, while in group 2 ICAM-1 showed a significant higher level and increased to 435.01 +/- 130.02 ng/ml (p < 0.001). The leukocyte count increased in both groups as well as the C-reactive protein (CRP) during the postoperative course. The CRP behaves similar in both groups (p = 0.636) in contrast to the leukocyte count which was significantly higher in group 2 (p < 0.01). While none of the patients in group 1 died the mortality in group 2 was 50 % (p < 0.001). Respiratory insufficiency after cardiopulmonary bypass is associated with a distinct increase in the ICAM-1. The reason for the increase of the ICAM-1 in this small subset of patients has not been clarified.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- C-Reactive Protein - analysis
- Cardiopulmonary Bypass -
- Case-Control Studies -
- Coronary Artery Bypass -
- Humans -
- Intercellular Adhesion Molecule-1 - blood
- Leukocyte Count -
- Middle Aged -
- Postoperative Complications - blood
- Respiratory Insufficiency - blood
- Respiratory Insufficiency - etiology
- Find related publications in this database (Keywords)
- pulmonary insufficiency
- ICAM-1
- cardiopulmonary bypass