Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Regittnig, W; Ellmerer, M; Fauler, G; Sendlhofer, G; Trajanoski, Z; Leis, HJ; Schaupp, L; Wach, P; Pieber, TR.
Assessment of transcapillary glucose exchange in human skeletal muscle and adipose tissue.
Am J Physiol Endocrinol Metab. 2003; 285(2):E241-E251
Doi: 10.1152/ajpendo.00351.2002
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- Führende Autor*innen der Med Uni Graz
- Regittnig Werner
- Co-Autor*innen der Med Uni Graz
- Ellmerer Martin
- Fauler Günter
- Leis Hans-Joerg
- Pieber Thomas
- Schaupp Lukas
- Sendlhofer Gerald
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- Abstract:
- We studied the kinetics of glucose exchange between plasma and interstitial fluid (ISF) in human skeletal muscle and adipose tissue under fasting conditions. Five normal human subjects received an intravenous [6,6-2H2]glucose infusion in a prime-continuous fashion. During the tracer infusion, the open-flow microperfusion technique was employed to frequently sample ISF from quadriceps muscle and subcutaneous adipose tissue. The tracer glucose kinetics observed in muscle and adipose tissue ISF were found to be well described by a capillary-tissue exchange model. As a measure of transcapillary glucose exchange efficiency, the 95% equilibrium time was calculated from the identified model parameters. This time constant was similar for skeletal muscle and adipose tissue (28.6 +/- 3.2 vs. 26.8 +/- 3.6 min; P = 0.60). Furthermore, we found that the (total) interstitial glucose concentration was significantly lower (P < 0.01) in muscle (3.32 +/- 0.46 mmol/l) and adipose tissue (3.51 +/- 0.17 mmol/l) compared with arterialized plasma levels (5.56 +/- 0.13 mmol/l). Thus the observed gradients and dynamic relationships between plasma and ISF glucose in muscle and adipose tissue provide evidence that transcapillary exchange of glucose is limited in these two tissues under fasting conditions.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue - blood supply Adipose Tissue - chemistry
- Adult -
- Arteries -
- Blood Glucose - metabolism
- Body Mass Index -
- Capillaries -
- Deuterium -
- Extracellular Space - metabolism
- Glucose - analysis Glucose - metabolism
- Humans -
- Kinetics -
- Male -
- Mannitol - administration & dosage Mannitol - analysis
- Mathematics -
- Muscle, Skeletal - blood supply Muscle, Skeletal - chemistry
- Find related publications in this database (Keywords)
- open-flow microperfusion
- interstitial fluid
- capillary-tissue exchange model