Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Jelovcan, S; Gutschi, A; Kleinhappl, B; Sedlmayr, P; Barth, S; Marth, E.
Effects of low concentrations of cadmium on immunoglobulin E production by human B lymphocytes in vitro.
Toxicology. 2003; 188(1):35-48
Doi: 10.1016/S0300-483X(03)00044-1
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Barth Sonja
- Kleinhappl Barbara
- Marth Egon
- Sedlmayr Peter
- Zauner Andrea
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- Abstract:
- Exposure to cadmium (Cd) can cause a variety of biological effects including alterations of immune responses in animals and humans. Both immunosuppression and immunoenhancement have been reported. The present study was aimed at investigating the consequences of exposure to Cd on the human immunoglobulin (Ig) E synthesis, using purified peripheral blood B lymphocytes and IL-4 and anti-human CD40 monoclonal antibody (a-CD40 mAb) as stimuli. Low concentrations of Cd (0.1-10 microM) markedly inhibited production of IgE in a concentration-dependent manner. IgG production, in contrast to IgE, showed a tendency towards being enhanced by Cd, although with a certain individual variability; IgM production was not affected. Cd failed to alter immediate surface expression of the activation markers CD69 and CD23 indicating that early activation events were not impaired. However, the portion of activated B cells was diminished by Cd after stimulation for more than 24 h, paralleled by a concomitant decrease in viability and a subsequent reduction in proliferation. These data suggest that the mechanism of Cd action on activated B cells involved pathways that interrupted an effectively initiated cell activation and induced a cytotoxic signal. Results from this study thus provide further evidence for and new information on the immunotoxic and immunomodulatory effects of Cd on human immune responses.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antibodies, Monoclonal - immunology
- Antigens, CD - biosynthesis Antigens, CD - immunology
- Antigens, CD40 - immunology
- Antigens, Differentiation, T-Lymphocyte - biosynthesis Antigens, Differentiation, T-Lymphocyte - immunology
- B-Lymphocytes - cytology B-Lymphocytes - drug effects B-Lymphocytes - immunology B-Lymphocytes - metabolism
- Cadmium - toxicity
- Cell Survival - immunology
- Dose-Response Relationship, Immunologic -
- Female -
- Flow Cytometry -
- Humans -
- Immunoglobulin E - biosynthesis Immunoglobulin E - immunology Immunoglobulin E - metabolism
- Immunoglobulin G - biosynthesis Immunoglobulin G - immunology
- Immunoglobulin M - biosynthesis Immunoglobulin M - immunology
- Interleukin-4 - immunology
- Lectins, C-Type -
- Lymphocyte Activation - immunology
- Male -
- Middle Aged -
- Receptors, IgE - biosynthesis Receptors, IgE - immunology
- Find related publications in this database (Keywords)
- cadmium
- B lymphocyte
- IgE synthesis
- B cell activation
- immunotoxicity