Medizinische Universität Graz - Research portal
Selected Publication:
Westphal, GA; Schnuch, A; Moessner, R; König, IR; Kränke, B; Hallier, E; Ziegler, A; Reich, K.
Cytokine gene polymorphisms in allergic contact dermatitis.
Contact Dermatitis. 2003; 48(2):93-98
Doi: 10.1034/j.1600-0536.2003.480208.x
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Kränke Birger
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Susceptibility to contact allergy may be influenced by genetically determined alterations in the production of pro- and anti-inflammatory cytokines. This report focuses on functional polymorphisms in the genes encoding for several cytokines involved in the pathogenesis of contact allergic responses, including tumour necrosis factor (TNF)-alpha (G-238 A, G-308 A), interleukin (IL)-1beta (C-511G, T+ 3953C), its natural antagonist, the IL-1 receptor antagonist (VNTR intron 2), and IL-6 (G-174C). Polymorphisms were investigated by PCR techniques among polysensitized individuals, defined as individuals with confirmed contact sensitization to para-substituted aryl compounds and at least one other structurally unrelated allergen (n = 86), and healthy control individuals without a history of eczema (n = 310). The distribution of TNFA-308 genotypes was significantly different in these groups (Padjusted= 0.0378). Compared with carriers of 2 wild-type alleles (TNFA-308*1/1 (*G/G)), carriers of the TNFA-308*1/2 (*G/A) and TNFA-308*2/2 (*A/A) genotypes tended to be more common among polysensitized individuals [OR = 1.54, 95% CI (0.92-2.55) and OR = 2.36 (0.84-6.51), respectively]. No significantly different distribution of genotypes was detected at any other polymorphic loci among control individuals without eczema and polysensitized subjects. These findings suggest a possible relationship between the TNFA-308 polymorphism and contact allergy. The results need to be confirmed in future studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age Distribution -
- Alleles -
- Austria - epidemiology
- Case-Control Studies - epidemiology
- Cytokines - genetics
- Dermatitis, Allergic Contact - epidemiology
- Dermatitis, Atopic - diagnosis
- Female - diagnosis
- Gene Frequency - diagnosis
- Genetic Predisposition to Disease - diagnosis
- Genotype - diagnosis
- Humans - diagnosis
- Incidence - diagnosis
- Interleukin-1 - analysis
- Male - analysis
- Middle Aged - analysis
- Polymorphism, Genetic - analysis
- Probability - analysis
- Receptors, Interleukin-1 - genetics
- Reference Values - genetics
- Sex Distribution - genetics
- Tumor Necrosis Factor-alpha - genetics
- Find related publications in this database (Keywords)
- gene polymorphism
- interleukin-1 beta
- interleukin-6
- tumour necrosis factor-alpha