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Selected Publication:
Hideghéty, K; Sauerwein, W; Wittig, A; Götz, C; Paquis, P; Grochulla, F; Haselsberger, K; Wolbers, J; Moss, R; Huiskamp, R; Fankhauser, H; de Vries, M; Gabel, D.
Tissue uptake of BSH in patients with glioblastoma in the EORTC 11961 phase I BNCT trial.
J Neurooncol. 2003; 62(1-2):145-156
Doi: 10.1023%2FA%3A1023201308434
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Haselsberger Klaus
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- Abstract:
- PURPOSE: The uptake of the boron compound Na2B12H10-SH (BSH) in tumor and normal tissues was investigated in the frame of the EORTC phase I trial 'Postoperative treatment of glioblastoma with BNCT at the Petten Irradiation Facility' (protocol 11961). METHODS AND MATERIALS: The boron concentration in blood, tumor, normal brain, dura, muscle, skin and bone was detected using inductively coupled plasma-atomic emission spectroscopy in 13 evaluable patients. In a first group of 10 patients 100 mg BSH/kg bodyweight (BW) were administered; a second group of 3 patients received 22.9 mg BSH/kg BW. The toxicity due to BSH was evaluated. RESULTS: The average boron concentration in the tumor was 19.9 +/- 9.1 ppm (1 standard deviation (SD)) in the high dose group and 9.8 +/- 3.3 ppm in the low dose group, the tumor/blood ratios were 0.6 +/- 0.2 and 0.9 +/- 0.2, respectively. The highest boron uptake has been detected in the dura, very low uptake was found in the bone, the cerebro-spinal fluid and especially in the brain (brain/blood ratio 0.2 +/- 0.02 and 0.4 +/- 0.2). No toxicity was detected except flush-like symptoms in 2 cases during a BSH infusion at a much higher speed than prescribed. CONCLUSION: BSH proved to be safe for clinical application at a dose of 100 mg BSH/kg infused and at a dose rate of 1 mg/kg/min. The study underlines the importance of a further investigation of BSH uptake in order to obtain enough data for significant statistical analysis. The boron concentration in blood seems to be a quite reliable parameter to predict the boron concentration in other tissues.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Boron - adverse effects
- Boron Compounds - administration and dosage
- Boron Neutron Capture Therapy - adverse effects
- Brain Neoplasms - radiotherapy
- Dose-Response Relationship, Radiation - radiotherapy
- Female - radiotherapy
- Glioblastoma - radiotherapy
- Humans - radiotherapy
- Male - radiotherapy
- Middle Aged - radiotherapy
- Radiotherapy Dosage - radiotherapy
- Tissue Distribution - radiotherapy
- Find related publications in this database (Keywords)
- BNCT
- glioblastoma
- BSH tissue uptake
- BSH toxicity