Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kudlacek, S; Schneider, B; Peterlik, M; Leb, G; Klaushofer, K; Weber, K; Woloszczuk, W; Willvonseder, R; Austrian Study Group on Normative Values of Bone Metabolism.
Normative data of bone mineral density in an unselected adult Austrian population.
Eur J Clin Invest. 2003; 33(4):332-339
Doi: 10.1046/j.1365-2362.2003.01128.x
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- Co-Autor*innen der Med Uni Graz
- Weber Kurt
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- Abstract:
- BACKGROUND: There is increasing evidence that correct interpretation of bone mineral density (BMD) measurements by dual energy X-ray absorptiometry (DEXA) requires a population-specific reference range. We therefore collected data on age-related BMD in a random sample of the normal adult Austrian population to establish an appropriate normative database. METHODS: We measured BMD by DEXA at five different skeletal sites in 1089 subjects, i.e. 654 females and 435 males, aged between 21-76 years, who had been recruited by 17 centres across Austria. RESULTS: Age-related bone loss was observed until age 65 years with significant changes at the lumbar spine (r = -0.23), total hip (r = -0.07), trochanter (r = -0.10), femoral neck (r = -0.30) and Ward's triangle (r = -0.40) in the women but only at the femoral neck (r = -0.23) and at Ward's triangle (r = -0.40) in the men. When we calculated T scores from the BMD data of the young normal adult study population and used the T score set points according to the WHO classification of osteopenia and osteoporosis, we found that, depending on the skeletal site measured, 7.6-27.4% of the women and 16-41% of the men in our study group had low bone mass, whereas 0.6-2.7% of the female and 0.2-1.0% of the male study population were osteoporotic. However, osteoporosis was indicated in 4-9-fold more females and 5-15-fold more males when we based our estimates on the normative data provided by the manufacturers of the DEXA systems. CONCLUSION: Our data underscore the importance of using a population-specific reference range for DEXA measurements to avoid overdiagnosis of osteoporosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Austria - epidemiology
- Bone Density - physiology
- Bone and Bones - physiology
- Densitometry, X-Ray - methods
- Female - methods
- Femur - physiology
- Femur Neck - physiology
- Hip - physiology
- Humans - physiology
- Male - physiology
- Middle Aged - physiology
- Osteoporosis - epidemiology
- Spine - physiology
- Find related publications in this database (Keywords)
- age
- bone loss
- dual energy X-ray absorptiometry
- femoral neck
- hip
- lumbar spine
- osteopenia
- osteoporosis
- T score
- trochanter
- Ward's triangle