Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kudlacek, S; Schneider, B; Peterlik, M; Leb, G; Klaushofer, K; Weber, K; Woloszczuk, W; Willvonseder, R; Austrian Study Group on Normative Values of Bone Metabolism.
Assessment of vitamin D and calcium status in healthy adult Austrians.
Eur J Clin Invest. 2003; 33(4):323-331
Doi: 10.1046/j.1365-2362.2003.01127.x
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- Co-Autor*innen der Med Uni Graz
- Weber Kurt
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- Abstract:
- BACKGROUND: Because there is reason to assume that also in Austria calcium and vitamin D malnutrition is wide-spread, we initiated a comprehensive study on calcium and vitamin D status in relation to bone health in a large group of the normal adult population. SUBJECTS AND METHODS: We assessed dietary calcium and vitamin D intake, serum concentrations of Ca2+, phosphate, alkaline phosphatase, 25(OH)D, 1,25(OH)2D, parathyroid hormone (PTH), follicle-stimulating hormone (FSH), sex hormones and bone mineral density (BMD) by double-energy X-ray absorptiometry at five different skeletal sites in 648 females and 400 males (age 21-76 years). RESULTS: Mean daily intake of vitamin D (101 IU, range 0.2-320) and calcium (569 mg, range 40-2170) was significantly less than the respective recommended dietary allowances. Two hundred and seventy-one (26%) individuals had hypovitaminosis D with serum 25(OH)D < 12 ng mL(-1), while serum Ca2+ was less than normal in 82 (7.8%) subjects. Multiple regression analysis revealed significant correlations between mean calcium intake and BMD in the femoral region in the men (r = 0.13, P < 0.05) though not in the women. No consistent data could be obtained for associations between BMD and vitamin D status, except for 25(OH)D and BMD at the spine in the men (r = 0.10, P < 0.05). 25(OH)D correlated negatively (P < 0.05) with age in the women (r = -0.11) and with PTH in the women (r = -0.11) and men (r = -0.16). Inversely, a significant (P < 0.001) age-related increase in PTH was observed in both sexes (men, r = 0.19; women, r = 0.14). CONCLUSIONS: Prevalence of hypovitaminosis D in adult Austrians is an imminent risk for development of secondary hyperparathyroidism with advancing age, and requires timely correction of nutritional deficits.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Austria - epidemiology
- Bone Density - physiology
- Calcium, Dietary - blood
- Densitometry, X-Ray - methods
- Diet - methods
- Female - methods
- Gonadal Steroid Hormones - blood
- Humans - blood
- Hyperparathyroidism - etiology
- Male - etiology
- Middle Aged - etiology
- Parathyroid Hormone - blood
- Vitamin D - blood
- Vitamin D Deficiency - complications
- Find related publications in this database (Keywords)
- 25-hydroxyvitamin D
- bone mineral density
- calcium intake
- hypovitaminosis D
- secondary hyperparathyroidism
- vitamin D intake