Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kühr, T; Burgstaller, S; Apfelbeck, U; Linkesch, W; Seewann, H; Fridrik, M; Michlmayr, G; Krieger, O; Lutz, D; Lin, W; Pont, J; Köck, L; Abbrederis, K; Baldinger, C; Buder, R; Geissler, D; Hausmaninger, H; Lang, A; Zabernigg, A; Duba, C; Hilbe, W; Eisterer, W; Fiegl, M; Greil, R; Gastl, G; Thaler, J; Austrian CML Study Group.
A randomized study comparing interferon (IFN alpha) plus low-dose cytarabine and interferon plus hydroxyurea (HU) in early chronic-phase chronic myeloid leukemia (CML).
Leuk Res. 2003; 27(5):405-411
Doi: 10.1016%2FS0145-2126%2802%2900223-0
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Apfelbeck Ute
- Linkesch Werner
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- Abstract:
- This multicenter randomized phase III study was designed to compare the efficacy and toxicity of IFN alpha-2c (3.5 MU/d) in combination with either araC (10 mg/m(2) d1-10) or hydroxyurea (HU: 25 mg/kg per day) in newly diagnosed CML patients. A total of 114 patients were randomized. Following a median observation period of 36 (range 1-73) months the major cytogenetic response rates were 25 and 27% and the 4-year survival probabilities 62.5 and 63% for the araC and HU group, respectively. While the overall toxicity profile was comparable between both groups, patients in the HU arm exhibited a slightly higher degree of WHO grades 3 and 4 non-hematological toxicities.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antineoplastic Combined Chemotherapy Protocols - adverse effects
- Cytarabine - administration and dosage
- Female - administration and dosage
- Gastrointestinal Diseases - chemically induced
- Hematologic Diseases - chemically induced
- Humans - chemically induced
- Hydroxyurea - administration and dosage
- Interferon Alfa-2c - administration and dosage
- Leukemia, Myeloid, Chronic-Phase - drug therapy
- Life Tables - drug therapy
- Male - drug therapy
- Middle Aged - drug therapy
- Nervous System Diseases - chemically induced
- Treatment Outcome - chemically induced
- Find related publications in this database (Keywords)
- CML
- interferon
- hydroxyurea
- cytarabine
- randomised study