Medizinische Universität Graz - Research portal
Selected Publication:
Wascher, TC; Paulweber, B; Malaimare, L; Stadlmayr, A; Iglseder, B; Schmoelzer, I; Renner, W.
Associations of a human G protein beta3 subunit dimorphism with insulin resistance and carotid atherosclerosis.
Stroke. 2003; 34(3):605-609
Doi: 10.1161/01.STR.0000058159.63950.EA
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- Leading authors Med Uni Graz
- Wascher Thomas
- Co-authors Med Uni Graz
- Renner Wilfried
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- Abstract:
- BACKGROUND AND PURPOSE: The C825T dimorphism of the gene encoding the human G protein beta3 subunit (GNB3) is associated with hypertension and obesity. Although these findings suggest an association with insulin resistance and atherosclerosis, this hypothesis has yet been tested only partially. METHODS: To investigate this hypothesis, the C825T dimorphism was determined in a population of 932 middle-aged white subjects of middle European (Austrian) origin. Insulin sensitivity was measured with the short insulin tolerance test; intima-media thickness of the carotid artery and morphological plaque burden were measured by ultrasound. RESULTS: Insulin sensitivity was found to be significantly lower in carriers of the T allele (3.55+/-1.27 versus 3.92+/-1.30%/min, P=0.012) in the group of male subjects with abdominal body fat distribution (waist-to-hip ratio >0.9). No effect was observed in women or men with a waist-to-hip ratio <0.9. Advanced carotid artery plaques were more frequent (odds ratio, 1.606; 95% confidence interval, 1.002 to 2.575; P=0.04) in carriers of the T allele regardless of sex. No effect was observed with regard to carotid artery intima-media thickness. CONCLUSIONS: In summary, our results demonstrate that the GNB3 825T allele is associated with reduced insulin sensitivity in men with abdominal fat distribution and with more advanced carotid atherosclerosis in middle-aged white men and women.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Alleles -
- Austria - epidemiology
- Blood Pressure - genetics
- Body Constitution - genetics
- Carotid Arteries - ultrasonography
- Carotid Artery Diseases - epidemiology
- Cohort Studies - epidemiology
- Comorbidity - epidemiology
- DNA Mutational Analysis - epidemiology
- European Continental Ancestry Group - genetics
- Female - genetics
- Gene Frequency - genetics
- Heterotrimeric GTP-Binding Proteins - genetics
- Humans - genetics
- Hypertension - epidemiology
- Insulin Resistance - genetics
- Male - genetics
- Middle Aged - genetics
- Polymorphism, Genetic - genetics
- Prevalence - genetics
- Protein Subunits - genetics
- Find related publications in this database (Keywords)
- atherosclerosis
- genetics
- insulin
- proteins