Medizinische Universität Graz - Research portal
Selected Publication:
Kollroser, M; Schober, C.
An on-line solid phase extraction - Liquid chromatography - Tandem mass spectrometry method for the analysis of citalopram, fluvoxamine, and paroxetine in human plasma
CHROMATOGRAPHIA 2003 57: 133-138.
Doi: 10.1007/BF02491705
Web of Science
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- Leading authors Med Uni Graz
- Kollroser Manfred
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- Abstract:
- A specific and sensitive direct-injection high performance liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry (HPLC-APCI-MS-MS) method has been developed for the rapid identification and quantitative determination of citalopram, fluvoxamine, and paroxetine in human plasma. After dilution with 0.1% formic acid, plasma samples were injected into the LC-MS-MS system. Proteins and other large biomolecules were removed during an on-line sample cleanup step. The inter- and intra-assay coefficients of variation for all compounds were < 11%. The total analysis time was 6 min per sample. The proposed method permits direct analysis of plasma samples without time-consuming sample preparation.
- Find related publications in this database (Keywords)
- column liquid chromatography
- MS-MS detection
- on-line sample clean-up
- citalopram
- fluvoxamine and paroxetine
- human plasma