Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Moser, A; Lackner, H; Deutsch, J; Kerbl, R; Schwinger, W; Dornbusch, HJ; Kessler, HH; Urban, C.
Dual infection with hepatitis B and C. Spontaneous course and response to virostatic therapy in children following neoplastic diseases
Wien Klin Wochenschr. 2003; 115(1-2):66-70
Doi: 10.1007/BF03040276
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Nebl Andrea Maria
- Co-Autor*innen der Med Uni Graz
- Deutsch Johann
- Dornbusch Hans Jürgen
- Kerbl Reinhold
- Kessler Harald
- Lackner Herwig
- Schwinger Wolfgang
- Urban Ernst-Christian
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- Abstract:
- Combined chronic hepatitis B and C is a long-term complication in children surviving malignancy. We report on seven children who acquired hepatitis B as well as C virus infection during treatment for different malignancies. Four patients showed a spontaneous HBe Ag/anti-HBe seroconversion, two patients spontaneous clearance of hepatitis C virus, and one patient showed both HBe Ag/anti-HBe seroconversion and clearance of hepatitis C virus. One patient developed HBe Ag/anti-HBe seroconversion after antiviral interferon monotherapy and another patient after combination therapy with interferon/famcyclovir. Three patients developed complete sustained response of hepatitis C to a combined virostatic therapy with interferon and ribavirin. A total of 4 of 7 patients had a clearance of both infections and 3 of 7 patients had a clearance of at least one infection. CONCLUSION: Our data in long-term survivors of childhood cancer with combined hepatitis B and C showed a remarkably high rate of spontaneous cure and a favourable response to antiviral therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Antiviral Agents - adverse effects
- Child - adverse effects
- Child, Preschool - adverse effects
- Drug Therapy, Combination - adverse effects
- Follow-Up Studies - adverse effects
- Hepatitis B Antibodies - blood
- Hepatitis B e Antigens - blood
- Hepatitis B, Chronic - diagnosis
- Hepatitis C Antibodies - blood
- Hepatitis C, Chronic - diagnosis
- Humans - diagnosis
- Infant - diagnosis
- Interferons - therapeutic use
- Male - therapeutic use
- Neoplasms - complications
- Treatment Outcome - complications
- Find related publications in this database (Keywords)
- hepatitis B
- hepatitis C virus
- children
- malignancy
- therapy