Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kapeller, P; Barber, R; Vermeulen, RJ; Adèr, H; Scheltens, P; Freidl, W; Almkvist, O; Moretti, M; del Ser, T; Vaghfeldt, P; Enzinger, C; Barkhof, F; Inzitari, D; Erkinjunti, T; Schmidt, R; Fazekas, F; European Task Force of Age Related White Matter Changes.
Visual rating of age-related white matter changes on magnetic resonance imaging: scale comparison, interrater agreement, and correlations with quantitative measurements.
Stroke. 2003; 34(2):441-445
Doi: 10.1161%2F01.STR.0000049766.26453.E9
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Fazekas Franz
- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Freidl Wolfgang
- Kapeller Peter
- Schmidt Reinhold
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND AND PURPOSE: To provide further insight into the MRI assessment of age-related white matter changes (ARWMCs) with visual rating scales, 3 raters with different levels of experience tested the interrater agreement and comparability of 3 widely used rating scales in a cross-sectional and follow-up setting. Furthermore, the correlation between visual ratings and quantitative volumetric measurement was assessed. METHODS: Three raters from different sites using 3 established rating scales (Manolio, Fazekas and Schmidt, Scheltens) evaluated 74 baseline and follow-up scans from 5 European centers. One investigator also rated baseline scans in a set of 255 participants of the Austrian Stroke Prevention Study (ASPS) and measured the volume of ARWMCs. RESULTS: The interrater agreement for the baseline investigation was fair to good for all scales (kappa values, 0.59 to 0.78). On the follow-up scans, all 3 raters depicted significant ARWMC progression; however, the direct interrater agreement for this task was poor (kappa, 0.19 to 0.39). Comparison of the interrater reliability between the 3 scales revealed a statistical significant difference between the scale of Manolio and that of Fazekas and Schmidt for the baseline investigation (z value, -2.9676; P=0.003), demonstrating better interrater agreement for the Fazekas and Schmidt scale. The rating results obtained with all 3 scales were highly correlated with each other (Spearman rank correlation, 0.712 to 0.806; P< or =0.01), and there was significant agreement between all 3 visual rating scales and the quantitative volumetric measurement of ARWMC (Kendall W, 0.37, 0.48, and 0.57; P<0.001). CONCLUSIONS: Our data demonstrate that the 3 rating scales studied reflect the actual volume of ARWMCs well. The 2 scales that provide more detailed information on ARWMCs seemed preferential compared with the 1 that yields more global information. The visual assessment of ARWMC progression remains problematic and may require modifications or extensions of existing rating scales.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Aging - physiology
- Brain - anatomy and histology
- Europe - anatomy and histology
- Follow-Up Studies - anatomy and histology
- Humans - anatomy and histology
- Image Processing, Computer-Assisted - anatomy and histology
- Magnetic Resonance Imaging - methods
- Middle Aged - methods
- Observer Variation - methods
- Reference Values - methods
- Reproducibility of Results - methods
- Sample Size - methods
- Sensitivity and Specificity - methods
- Stroke - prevention and control
- Find related publications in this database (Keywords)
- magnetic resonance imaging
- white matter