Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Mayer, R; Stranzl, H; Prettenhofer, U; Quehenberger, F; Stücklschweiger, G; Winkler, P; Hackl, A.
Palliative treatment of unresectable bile duct tumours.
Acta Med Austriaca. 2003; 30(1):10-12
Doi: 10.1046/j.1563-2571.2003.02049.x
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Mayer Ramona
- Co-Autor*innen der Med Uni Graz
- Hackl Arnulf
- Prettenhofer Ulrike
- Quehenberger Franz
- Stranzl-Lawatsch Heidi
- Winkler Peter
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- Abstract:
- Purpose: Report on outcome of intraluminal high-dose-rate iridium-192 (HDR-Ir-192) brachytherapy with or without external radiotherapy in patients with unresectable bile duct tumours suffering from symptoms of malignant obstructive jaundice. Material and methods: Fourteen patients (mean age: 63 years) who were unsuitable for surgical resection on preoperative evaluation/laparotomy or inoperable due to poor general condition were referred for palliative radiotherapy. After percutaneous transhepatic drainage, HDR-Ir-192 brachytherapy was performed with a single dose of 2.5 Gy. Brachytherapy was given twice a day with at least a 6-h interval for 2 days, 2 or 3 days apart, up to a total dose of 10 Gy. Five patients received small-volume external radiotherapy (RT) (45 - 50.4 Gy/1.8 Gy) additionally. Results: Palliation with relief of the aggravating symptoms of obstructive jaundice was achieved in all patients. The actuarial 2-year survival rate of all patients was 11.9 % with a median survival of 6.5 months. Patients treated with brachytherapy alone had a median survival of 4.5 months as compared with 6.5 months after combined internal and external irradiation (log rank, P = 0.95). Conclusion: Patients with advanced unresectable bile duct cancer face a dismal prognosis; however, biliary drainage, and intraluminal brachytherapy with or without external RT, seem to be able to improve quality of life in the remaining time span.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Bile Duct Neoplasms - mortality Bile Duct Neoplasms - radiotherapy Bile Duct Neoplasms - therapy
- Brachytherapy -
- Cholestasis - etiology Cholestasis - therapy
- Drainage - methods
- Humans -
- Iridium Radioisotopes - therapeutic use
- Middle Aged -
- Palliative Care -
- Survival Analysis -
- Time Factors -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- malignant bile duct obstruction
- intraluminal brachytherapy
- external photon irradiation