Medizinische Universität Graz - Research portal
Selected Publication:
Rinner, I; Felsner, P; Falus, A; Skreiner, E; Kukulansky, T; Globerson, A; Hirokawa, K; Schauenstein, K.
Cholinergic signals to and from the immune system.
Immunol Lett. 1995; 44(2-3):217-220
Doi: 10.1016%2F0165-2478%2894%2900220-L
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Schauenstein Konrad
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- This article reviews recent data from our laboratory towards the impact of the autonomous nervous system on mutual interactions between the immune system and the central nervous system. Using a pharmacological approach in rats it is shown that shifts in the adrenergic/cholinergic balance in vivo affect in vitro functions of the non-specific and specific immune system, whereby adrenergic and cholinergic stimulation in general have opposite effects. A high degree of integration appears to exist between cells of the immune system with the cholinergic system. Lymphocytes were found to react to acetylcholine, but are also able to produce and to degradate this neurotransmitter. In addition, changes in the cholinergic tonus were found to affect immune signaling to the brain and to protect thymocytes from apoptosis, possibly via a direct effect on thymic epithelial cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenergic Agents - metabolism
- Animals - metabolism
- Cell Communication - metabolism
- Cholinergic Agents - metabolism
- Immune System - physiology
- Nervous System Physiology - physiology
- Rats - physiology
- Rats, Sprague-Dawley - physiology
- Find related publications in this database (Keywords)
- Immune-Neuroendocrine Interaction
- Adrenergic
- Cholinergic Signal
- Immune Function
- Apoptosis
- Thymus Epithelium