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Selected Publication:
Santucci, M; Pimpinelli, N; Massi, D; Kadin, ME; Meijer, CJ; Müller-Hermelink, HK; Paulli, M; Wechsler, J; Willemze, R; Audring, H; Bernengo, MG; Cerroni, L; Chimenti, S; Chott, A; Díaz-Pérez, JL; Dippel, E; Duncan, LM; Feller, AC; Geerts, ML; Hallermann, C; Kempf, W; Russell-Jones, R; Sander, C; Berti, E; EORTC Cutaneous Lymphoma Task Force.
Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force Workshop.
Cancer. 2003; 97(3):610-627
Doi: 10.1002/cncr.11107
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- Co-authors Med Uni Graz
- Cerroni Lorenzo
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- Abstract:
- BACKGROUND: Cutaneous lymphomas expressing a cytotoxic or natural killer (NK) cell phenotype represent a group of lymphoproliferative disorders for which there is currently much confusion and little consensus regarding the best nomenclature and classification. METHODS: This study analyzes 48 cases of primary cutaneous lymphoma expressing cytotoxic proteins and/or the NK cell marker, CD56. These cases were collected for a workshop of the European Organization for Research and Treatment of Cancer Cutaneous Lymphoma Task Force, to better clarify the clinical, morphologic, and phenotypic features of these uncommon tumors. RESULTS: Several categories with different clinical and pathologic features were delineated: 1) aggressive, CD8+, epidermotropic, cytotoxic T-cell lymphoma; 2) mycosis fungoides, cytotoxic immunophenotype variant; 3) subcutaneous panniculitis-like T-cell lymphoma; 4) NK/T-cell lymphoma, nasal type; 5) CD4+, NK cell lymphoma; 6) blastoid NK cell lymphoma; (7) intravascular NK-like lymphoma; and 8) cytotoxic, peripheral T-cell lymphoma. CONCLUSIONS: Our data show that primary cutaneous cytotoxic/NK cell lymphomas include distinct groups of diseases, clinically, histologically, and biologically. Because the finding of a cytotoxic phenotype often has prognostic significance, the routine use of cytotoxic markers in the diagnosis and classification of cutaneous lymphomas should be expanded.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens, CD56 - immunology
- CD4-Positive T-Lymphocytes - immunology
- CD8-Positive T-Lymphocytes - immunology
- Humans - immunology
- Immunophenotyping - immunology
- Killer Cells, Natural - immunology
- Lymphoma - classification
- Lymphoma, T-Cell, Cutaneous - classification
- Lymphoma, T-Cell, Peripheral - classification
- Membrane Proteins - immunology
- Mycosis Fungoides - immunology
- Panniculitis - immunology
- Phenotype - immunology
- Poly(A)-Binding Proteins - immunology
- Proteins - immunology
- RNA-Binding Proteins - immunology
- Skin Neoplasms - classification
- Find related publications in this database (Keywords)
- cytotoxic/NK cell lymphomas
- skin
- classification
- CD56
- TIA-1
- prognosis
- therapy