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Wasler, A; Radovancevic, B; Fruhwald, F; Tripolt, M; Klein, W; Tscheliessnigg, K.
First use of the Cancion cardiac recovery system in a human.
ASAIO J. 2003; 49(1):136-138 Doi: 10.1097%2F00002480-200301000-00023 (- Case Report)
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Leading authors Med Uni Graz: Wasler Andrae
Co-authors Med Uni Graz: Fruhwald Friedrich; Tscheliessnigg Karlheinz
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Abstract:: Animal studies have shown clearly that a peripheral circulatory support system can effectively unload the left ventricle. We report here the first implantation of one such system (Cancion, Orqis Medical, Lake Forest, CA) in a human. The Cancion system consists of a centrifugal pump connected to the circulation via a graft cannula anastomosed to the left axillary artery and a percutaneous cannula placed into the left common femoral artery. Flow is initiated from the femoral to the axillary artery. The system was implanted in a 62-year-old man with ischemic cardiomyopathy suffering from decompensation whose condition had not improved with catecholamine therapy. The Cancion system supported the patient for 3 days, after which it was electively explanted. During the support period, pulmonary capillary wedge pressure dramatically decreased from 28 to 9 mm Hg, left ventricular diastolic dimension decreased from 6.78 to 6.16 cm, creatinine levels decreased from 1.9 to 0.9 mg/dl, cardiac index improved from 1.5 to 2.7 L/min, and ejection fraction improved from 25 to 35%. Together, our data indicate that the Cancion system quickly and effectively improved the patient's hemodynamics. This suggests that the device may one day become a short-term alternative to high dose inotrope therapy and that its application may delay the need for more invasive forms of mechanical circulatory support.
Find related publications in this database (using NLM MeSH Indexing): Blood Pressure -; Cardiac Output -; Cardiomyopathies - surgery; Heart Failure, Congestive - surgery; Heart Transplantation - surgery; Heart-Assist Devices - surgery; Humans - surgery; Male - surgery; Middle Aged - surgery; Pulmonary Wedge Pressure - surgery; Waiting Lists - surgery