Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Klein, WW; Jackson, G; Tavazzi, L.
Efficacy of monotherapy compared with combined antianginal drugs in the treatment of chronic stable angina pectoris: a meta-analysis.
Coron Artery Dis. 2002; 13(8):427-436
Doi: 10.1097%2F00019501-200212000-00008
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Klein Werner
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- Abstract:
- OBJECTIVE: To determine the relative efficacy of antianginal drugs administered as monotherapy or in combination in patients with chronic stable angina. METHODS: A meta-analysis was performed on randomized trials, published in English between 1980 and 1999, that directly compared combined treatment and monotherapy. Twenty-two articles were included, all on the comparison of -blocker monotherapies to their combination with a calcium antagonist and 10 on the comparison of calcium antagonist monotherapies to their combination with a -blocker. RESULTS: Time to 1 mm ST-segment depression, total exercise duration and time to onset of anginal pain were significantly increased with the combined therapy compared to -blocker alone (by 8, 5 and 12%, respectively). Only time to 1 mm ST-segment depression was significantly increased with the combined therapy compared to calcium antagonist alone (by 9%). For all these parameters, the adjusted differences were significant only within 6 h following drug intake and were not significant after 6 h. No analysis of safety data could be performed. CONCLUSION: As far as exercise testing is concerned, the combination of a calcium antagonist and a -blocker is statistically more effective than either monotherapy. Further studies are needed to confirm the higher efficacy after the first 6 h following drug intake.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenergic beta-Antagonists - therapeutic use
- Angina Pectoris - diagnosis
- Calcium Channel Blockers - therapeutic use
- Chronic Disease - therapeutic use
- Coronary Angiography - therapeutic use
- Cross-Over Studies - therapeutic use
- Drug Therapy, Combination - therapeutic use
- Electrocardiography - therapeutic use
- Exercise Test - therapeutic use
- Humans - therapeutic use
- Randomized Controlled Trials - therapeutic use
- Reproducibility of Results - therapeutic use
- Time Factors - therapeutic use
- Treatment Outcome - therapeutic use
- Find related publications in this database (Keywords)
- meta-analysis
- chronic stable angina
- beta-blocker
- calcium antagonist
- monotherapy
- combined antianginal drugs