Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Jakesz, R; Hausmaninger, H; Kubista, E; Gnant, M; Menzel, C; Bauernhofer, T; Seifert, M; Haider, K; Mlineritsch, B; Steindorfer, P; Kwasny, W; Fridrik, M; Steger, G; Wette, V; Samonigg, H; Austrian Breast and Colorectal Cancer Study Group Trial 5.
Randomized adjuvant trial of tamoxifen and goserelin versus cyclophosphamide, methotrexate, and fluorouracil: evidence for the superiority of treatment with endocrine blockade in premenopausal patients with hormone-responsive breast cancer--Austrian Breast and Colorectal Cancer Study Group Trial 5.
J CLIN ONCOL 2002 20: 4621-4627.
Doi: 10.1200%2FJCO.2002.09.112
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Bauernhofer Thomas
- Kronberger Leo
- Samonigg Hellmut
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- PURPOSE: Effective adjuvant treatment modalities in premenopausal breast cancer patients today include chemotherapy, ovariectomy, and tamoxifen administration. The purpose of Austrian Breast and Colorectal Cancer Study Group Trial 5 was to compare the efficacy of a combination endocrine treatment with standard chemotherapy. PATIENTS AND METHODS: Assessable trial subjects (N = 1,034) presenting with hormone-responsive disease were randomized to receive either 3 years of goserelin plus 5 years of tamoxifen or six cycles of cyclophosphamide, methotrexate, and fluorouracil (CMF). Stratification criteria included tumor stage and grade, number of involved nodes, type of surgery, and steroid hormone receptor content. Relapse-free survival (RFS) was defined as time from randomization to first relapse, local recurrence, or contralateral incidence, and overall survival (OS) as time to date of death. RESULTS: With a 60-month median follow-up, 17.2% of patients in the endocrine group and 20.8% undergoing chemotherapy developed relapses. Local recurrences emerged in 4.7% and 8.0%, respectively. RFS and local recurrence-free survival differed significantly in favor of endocrine therapy (P =.037 and P =.015), with a similar trend observed in OS (P =.195). CONCLUSION: Overall, our data suggest that the goserelin-tamoxifen combination is significantly more effective than CMF in the adjuvant treatment of premenopausal patients with stage I and II breast cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents, Hormonal - administration and dosage
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Breast Neoplasms - mortality
- Chemotherapy, Adjuvant - mortality
- Comparative Study - mortality
- Cyclophosphamide - therapeutic use
- Female - therapeutic use
- Fluorouracil - therapeutic use
- Goserelin - administration and dosage
- Humans - administration and dosage
- Methotrexate - therapeutic use
- Neoplasm Recurrence, Local - therapeutic use
- Ovariectomy - therapeutic use
- Premenopause - therapeutic use
- Survival Rate - therapeutic use
- Tamoxifen - administration and dosage