Medizinische Universität Graz - Research portal
Selected Publication:
Horn, S; Aglas, F; Horina, JH.
Cholestasis and liver cell damage due to hypersensitivity to erythromycin stearate--recurrence following therapy with erythromycin succinate
WIEN KLIN WOCHENSCHR. 1999; 111: 76-77.
(- Case Report)
Web of Science
PubMed
- Leading authors Med Uni Graz
- Horn Sabine
- Co-authors Med Uni Graz
- Horina Joerg
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- Abstract:
- Erythromycin is a frequently used antibiotic in patients with atypical respiratory infection and/or an allergy to penicillin. We report the case of a young woman who developed severe cholestasis and jaundice following treatment with erythromycin stearate. Two years later her general practitioner prescribed erythromycin succinate for pharyngitis. She experienced a severe second episode of jaundice and malaise. Different esters of erythromycin have been introduced to reduce side effects such as allergic reactions to erythromycin. The findings in our patient underline the fact that hypersensitivity is caused by the erythromycin molecule, independent from the type of esterification. Because of these side effects newer makrolides should be given preference over erythromycin.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anti-Bacterial Agents - administration and dosage
- Cholestasis, Intrahepatic - chemically induced
- Drug Hypersensitivity - diagnosis
- Erythromycin - administration and dosage
- Erythromycin Ethylsuccinate - administration and dosage
- Female - administration and dosage
- Hepatitis, Toxic - diagnosis
- Humans - diagnosis
- Recurrence - diagnosis
- Retreatment - diagnosis
- Structure-Activity Relationship - diagnosis
- Find related publications in this database (Keywords)
- Makrolides
- Erythromycin Succinate
- Erythromycin Stearate
- Cholestasis
- Hypersensitivity