Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Denk, H; Stumptner, C; Fuchsbichler, A; Müller, T; Farr, G; Müller, W; Terracciano, L; Zatloukal, K.
Are the Mallory bodies and intracellular hyaline bodies in neoplastic and non-neoplastic hepatocytes related?
J PATHOL. 2006; 208: 653-661.
Doi: 10.1002/path.1946
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- Führende Autor*innen der Med Uni Graz
- Denk Helmut
- Co-Autor*innen der Med Uni Graz
- Stumptner Cornelia
- Zatloukal Kurt
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- Abstract:
- Mallory bodies (MBs) and intracellular hyaline bodies (IHBs) are cytoplasmic hepatocellular inclusions that consist of aggregated proteins. MBs are characteristically associated with alcoholic and non-alcoholic steatohepatitis, but may also be found in chronic cholestatic and metabolic (eg copper intoxication) diseases and hepatocellular neoplasms, particularly hepatocellular carcinomas. IHBs have hitherto only been described in hepatocellular carcinoma cells. In the present study hepatocellular carcinomas (HCCs) and a case of idiopathic copper toxicosis were evaluated with respect to the presence and mutual relationship of MBs and IHBs. IHBs alone were present in 8.6%, MBs alone in 16.1% and both types of inclusion in 7.5% of HCCs. It is shown that IHBs may also occur in non-neoplastic hepatocytes in association with idiopathic copper toxicosis, together with MBs. In HCCs and idiopathic copper toxicosis, MBs and IHBs may be present within the same cell. Moreover, hybrid inclusions holding an intermediate position between MBs and IHBs regarding light microscopy, ultrastructure and composition exist. MBs and IHBs contain p62, a stress-inducible adapter protein, as the major constituent. In MBs p62 is associated with keratins, whereas classical IHBs lack keratins. Light microscopic, electron microscopic and immunohistochemical data suggest a close pathogenetic relationship between MBs and IHBs. Both types of inclusion are the result of over-expression and accumulation of the stress protein p62. If p62 is induced alone, or at least prevails, IHBs may arise by aggregation. However, if abnormal keratins are present in addition to p62, p62 associates and co-aggregates with keratins, finally leading to classical MBs.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Hepatocellular - metabolism
- Copper - poisoning
- Hepatocytes - metabolism
- Humans - metabolism
- Hyalin - metabolism
- Inclusion Bodies - metabolism
- Keratins - metabolism
- Liver Diseases - chemically induced
- Liver Neoplasms - metabolism
- Microscopy, Electron - metabolism
- Microscopy, Immunoelectron - metabolism
- Neoplasm Proteins - metabolism
- RNA-Binding Proteins - metabolism
- Find related publications in this database (Keywords)
- hepatocellular carcinoma
- copper toxicosis
- steatohepatitis
- keratins
- p62
- Mallory bodies
- intracellular hyaline bodies