Medizinische Universität Graz - Research portal
Selected Publication:
Pantoni, L; Simoni, M; Pracucci, G; Schmidt, R; Barkhof, F; Inzitari, D.
Visual rating scales for age-related white matter changes (leukoaraiosis): can the heterogeneity be reduced?
Stroke. 2002; 33(12):2827-2833
Doi: 10.1161/01.STR.0000038424.70626.5E
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- Co-authors Med Uni Graz
- Schmidt Reinhold
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- Abstract:
- BACKGROUND AND PURPOSE: It has been hypothesized that the use of different visual rating scales partly explains the discordant results of studies investigating risk factors and clinical correlates of age-related cerebral white matter changes (leukoaraiosis). We aimed to compare 6 widely used rating scales for leukoaraiosis and to calculate conversion coefficients of the score of 1 scale in the score of a second scale. METHODS: Two trained raters evaluated 80 pairs of CT and MRI scans using 2 CT and 4 MRI rating scales for white matter changes. Correlations among the scales were evaluated and regression lines were constructed with each of the CT and MRI scale scores as variables. RESULTS: A high correlation was observed in all the paired comparisons of the 6 scales (Spearman's rho ranging from 0.85 to 0.96, P<0.0001). Using regression analysis, we determined numeric parameters to transform the score of 1 scale to the corresponding score for each of the remaining scales and relative confidence intervals. The predictive values of these conversions expressed as R(2) ranged from 0.75 to 0.92. CONCLUSIONS: The present findings support the view that a good correlation exists among the considered visual rating scales for white matter changes. With the limitation that conversion parameters are calculated by applying a linear regression to partly nonlinear scales, their use allows comparison of the results of previous studies that used different scales and to pool data from past and ongoing clinical trials.
- Find related publications in this database (using NLM MeSH Indexing)
- Aging -
- Brain - radiography
- Brain Diseases - complications
- Cognition Disorders - complications
- Feasibility Studies - complications
- Gait Disorders, Neurologic - complications
- Humans - complications
- Hypertension - complications
- Linear Models - complications
- Magnetic Resonance Imaging - complications
- Middle Aged - complications
- Predictive Value of Tests - complications
- Risk Factors - complications
- Sensitivity and Specificity - complications
- Statistics, Nonparametric - complications
- Tomography, X-Ray Computed - complications
- Find related publications in this database (Keywords)
- leukoaraiosis
- magnetic resonance imaging
- tomography
- x-ray computed
- white matter