Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fazekas, F; Ropele, S; Enzinger, C; Seifert, T; Strasser-Fuchs, S.
Quantitative magnetization transfer imaging of pre-lesional white-matter changes in multiple sclerosis.
Mult Scler. 2002; 8(6):479-484
Doi: 10.1191/1352458502ms860oa
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- Führende Autor*innen der Med Uni Graz
- Fazekas Franz
- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Fuchs Siegrid
- Ropele Stefan
- Seifert-Held Thomas
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- Abstract:
- Objective: Previous magnetization transfer (MT) studies in multiple sclerosis (MS) suggest a reduction of the MT ratio (MTR) precedes new lesion development. To gain further insight into pre-lesional tissue abnormalities, we investigated the time course of additional quantitative MT parameters. Methods. Serial magnetic resonance imaging (MRI), including a gadolinium-enhanced TI scan and MT imaging by means of a FastPACE sequence, was performed on 12 patients (4 males, 8 females) with relapsing-remitting MS. Quantitative MT values including the magnetization exchange rate (k(for)) and the native relaxation time (TIfree) were analysed in the six months prior to the appearance of 44 enhancing lesions and in 88 control regions of persistently normal-appearing white matter (NAWM). Results. Appearance of new active lesions was preceded by a significant decrease of the MTR (F-7,F-166 = 91.5; p < 0.0001) and of k(for) (F-7,F-166= 105.2; p < 0.0001), and by an increase of TIfree (F-7,F-166 = 57.3; p < 0.0001). The drop of k(for) was the most pronounced pre-lesional change and together with the MTR was statistically significant already four months before the appearance of new lesion. The observed increase of TIfree was relatively small. MT variables of reactivated lesions were always different from NAWM but showed no characteristic time course. Conclusions. Multi-parametric MT measurements suggest both a reduction of macromolecular material and a focal increase of free water to occur several months before the appearance of an active lesion. Reduction of the magnetization exchange rate, which may result from primary damage to myelin, appears to be the leading event.
- Find related publications in this database (using NLM MeSH Indexing)
- Adjuvants, Immunologic - administration & dosage
- Adult -
- Female -
- Gadolinium - diagnostic use
- Humans -
- Interferon-beta - administration & dosage
- Magnetic Resonance Imaging - methods
- Male -
- Multiple Sclerosis, Relapsing-Remitting - drug therapy
- Nerve Fibers - pathology
- Find related publications in this database (Keywords)
- frequent magnetic resonance imaging
- magnetization transfer
- multiple sclerosis
- pre-lesional tissue changes