Medizinische Universität Graz - Research portal
Selected Publication:
Seifert, T; Kieseier, BC; Ropele, S; Strasser-Fuchs, S; Quehenberger, F; Fazekas, F; Hartung, HP.
TACE mRNA expression in peripheral mononudear cells precedes new lesions on MRI in multiple sclerosis.
MULT SCLER 2002 8: 447-451.
Doi: 10.1191%2F1352458502ms830oa
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Seifert-Held Thomas
- Co-authors Med Uni Graz
- Fazekas Franz
- Fuchs Siegrid
- Quehenberger Franz
- Ropele Stefan
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- Abstract:
- Tumor necrosis factor-alpha (TNF-alpha) is involved in the pathogenesis of multiple sclerosis (MS). It has to be released from its cell membrane-bound precursor by proteolytic cleavage. This is mainly performed by a member of the ADAM (a disintegrin and metalloproteinase) family of enzymes, TNF-alpha-converting enzyme (TACE, ADAM 17). In a longitudinal study on 11 relapsing-remitting MS patients, we qualitatively determined mRNA expression of TNF-alpha and TACE in peripheral blood mononuclear cells (PBMCs) without ex vivo stimulation. mRNA expression was related to disease activity as assessed by monthly gadolinium (Gd)-enhanced brain magnetic resonance imaging (MRI). Patients found positive for TACE mRNA in PBMCs showed a significantly higher mean number of new Gd-enhancing lesions per scan one month following PBMC sampling.
- Find related publications in this database (using NLM MeSH Indexing)
- ADAM Proteins -
- Adult -
- Blood-Brain Barrier - immunology
- Brain - immunology
- Enzyme Induction - immunology
- Female - immunology
- Gadolinium - diagnostic use
- Gene Expression Regulation, Enzymologic - diagnostic use
- Humans - diagnostic use
- Leukocytes, Mononuclear - enzymology
- Longitudinal Studies - enzymology
- Magnetic Resonance Imaging - enzymology
- Male - enzymology
- Metalloendopeptidases - genetics
- Multiple Sclerosis, Relapsing-Remitting - immunology
- RNA, Messenger - analysis
- Research Support, Non-U.S. Gov't - analysis
- Tumor Necrosis Factor-alpha - metabolism
- Find related publications in this database (Keywords)
- multiple sclerosis
- TACE
- TNF-alpha