Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Deutschmann, HA; Weger, M; Weger, W; Kotanko, P; Deutschmann, MJ; Skrabal, F.
Search for occult secondary osteoporosis: impact of identified possible risk factors on bone mineral density.
J Intern Med. 2002; 252(5):389-397
Doi: 10.1046/j.1365-2796.2002.01040.x
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- Führende Autor*innen der Med Uni Graz
- Deutschmann Hannes
- Co-Autor*innen der Med Uni Graz
- Weger Martin
- Weger Wolfgang
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- Abstract:
- To determine whether the use of more elaborate diagnostic tests can identify possible risk factors for secondary osteoporosis and to evaluate the impact of these possible risk factors on the severity of bone disease in the study population. Cross-sectional study. We have investigated 377 subjects (285 females, 92 males) with osteoporosis (T-score less than -2.5 in dual energy X-ray absorption) or nontraumatic lumbar vertebral fractures; these patients were referred to our hospital, a secondary care centre, for evaluation and treatment of osteoporosis. Osteoporosis without attributable risk factor was diagnosed in 106 women (37%) and 30 men (33%). In 241 patients (179 women, 62 men) one or more possible risk factors for osteoporosis (in this paper also called subclinical disease) were revealed. The most common were lactose malabsorption, disturbed exocrine pancreatic function and renal tubular disturbances, including renal hypercalciuria, incomplete renal tubular acidosis and mild phosphate diabetes. The number of possible risk factors in the individual patient was significantly related to the severity of osteoporosis as assessed by Z-scores (Spearman correlation r = -0.43, P < 0.001, n = 172 for females; r = -0.28, P < 0.05, n = 65 for males). All the identified subclinical diseases would have remained undetected if the currently accepted guidelines for the investigation of patients with osteoporosis were applied. The statistically significant correlation between the number of identified possible risk factors and the severity of bone disease in the individual patient strongly suggests the pathogenetic significance of the identified subclinical diseases. It is yet to be shown, whether specific treatment of these subclinical diseases yields additional improvement of bone mass as compared with standard treatment of osteoporosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Absorptiometry, Photon - methods
- Aged -
- Aged, 80 and over -
- Bone Density -
- Cohort Studies -
- Female -
- Humans -
- Lumbar Vertebrae - injuries
- Male -
- Medical History Taking -
- Middle Aged -
- Osteoporosis - diagnosis Osteoporosis - physiopathology
- Risk Factors -
- Find related publications in this database (Keywords)
- bone mineral density
- clinical guidelines
- lactose malabsorption
- renal tubular acidosis
- risk factors
- secondary osteoporosis