Medizinische Universität Graz - Research portal
Selected Publication:
Renner, W; Cichocki, L; Forjanics, A; Köppel, H; Gasser, R; Pilger, E.
G-455A polymorphism of the fibrinogen beta gene and deep vein thrombosis.
Eur J Clin Invest. 2002; 32(10):755-758
Doi: 10.1046%2Fj.1365-2362.2002.01070.x
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Renner Wilfried
- Co-authors Med Uni Graz
- Gasser Robert
- Köppel Herwig
- Pilger Ernst
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- Abstract:
- BACKGROUND: Elevated fibrinogen levels have been linked to increased risk for deep venous thrombosis, although it is not clear whether fibrinogen is causal or rather a marker for the presence of other risk factors. A common G/A polymorphism in the gene for the fibrinogen beta-chain (FGB G-455A) is associated with elevated fibrinogen levels. The present study was designed to analyze the role of this genetic marker for deep venous thrombosis. MATERIALS AND METHODS: We performed a case-control study including 307 patients with documented deep venous thrombosis and 316 control subjects. beta-fibrinogen genotypes were determined by allele-specific polymerase chain reaction. RESULTS: GG, GA and AA genotype frequencies were similar among the patients (53.1%, 41.0, 5.9) and controls (51.6%, 42.1, 6.3; P = 0.92). Fibrinogen levels of the patients (median 3.72 g l-1; range 1.93-11.6) did not differ significantly from those of the controls (3.76; 2.17-9.99). Carriers of the homozygous AA genotype had significantly higher fibrinogen levels than noncarriers (patients: 5.32 vs. 3.59; P = 0.024; controls: 6.29 vs. 3.72; P = 0.048). CONCLUSION: Our data suggest that the fibrinogen-elevating FGB G-455A gene polymorphism is not linked to an increased risk for deep venous thrombosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Alleles -
- Case-Control Studies -
- Fibrinogen - genetics
- Genes, APC - genetics
- Genetic Markers - genetics
- Genetic Predisposition to Disease - genetics
- Genotype - genetics
- Humans - genetics
- Polymorphism, Genetic - genetics
- Risk Factors - genetics
- Venous Thrombosis - genetics
- Find related publications in this database (Keywords)
- deep vein thrombosis
- fibrinogen
- gene
- polymorphism
- risk factor