Medizinische Universität Graz - Research portal
Selected Publication:
Amann, R; Lanz, I; Schuligoi, R.
Effects of morphine on oedema and tissue concentration of nerve growth factor in experimental inflammation of the rat paw.
Pharmacology. 2002; 66(3):169-172
Doi: 10.1159/000063800
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Leading authors Med Uni Graz
- Amann Rainer
- Co-authors Med Uni Graz
- Schuligoi Rufina
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Injection of carrageenan (1 mg) into the rat hind paw caused a time-dependent increase in paw volume that was maximal 3 h after injection. At this time, the concentration of nerve growth factor (NGF) in the skin of the inflamed paw was more than twofold higher than in the contralateral, non-inflamed paw. Treatment of rats with indomethacin reduced inflammatory oedema by 57%, morphine treatment attenuated oedema by 62%. While indomethacin had no statistically significant effect on the concentration of NGF in the skin of inflamed paws, morphine attenuated the NGF response by 24.2% in a naloxone reversible manner. These data suggest that drug-induced inhibition of inflammatory oedema is not predictive of its effect on an inflammation-induced rise in tissue NGF. Furthermore, our results confirm and extend previous observations suggesting an anti-inflammatory activity of morphine.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Edema - drug therapy
- Hindlimb - drug effects
- Inflammation - drug therapy
- Male - drug therapy
- Morphine - pharmacology
- Nerve Growth Factor - antagonists and inhibitors
- Rats - antagonists and inhibitors
- Rats, Sprague-Dawley - antagonists and inhibitors
- Find related publications in this database (Keywords)
- nerve growth factor
- non-steroidal anti-inflammatory drugs
- opioid