Medizinische Universität Graz - Research portal
Selected Publication:
Fargnoli, MC; Peris, K; Francesconi, F; Cantonetti, M; Cerroni, L; Chimenti, S.
Granulomatous mycosis fungoides responsive to gemcitabine.
Eur J Dermatol. 2002; 12(5):479-481
(- Case Report)
[OPEN ACCESS]
Web of Science
PubMed
- Co-authors Med Uni Graz
- Cerroni Lorenzo
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- Abstract:
- We report a 61-year-old woman with a 1-year-history of widespread erythematous scaly patches and plaques as well as red/purplish to brownish confluent plaques. Ulcerated lesions with a purulent, hemorrhagic exudate and sharp elevated borders were located on the lower extremities. Diagnosis of granulomatous mycosis fungoides was supported by histopathologic findings showing an inflammatory reaction with epithelioid and large giant cells associated with features characteristic of mycosis fungoides. Immunohistochemical studies showed a T-helper phenotype of neoplastic cells (CD3+, CD4+, CD45RO+) with expression of the cytotoxic protein TIA-1. Molecular analysis of TCRgamma gene demonstrated a monoclonal rearrangement in the lesional skin. After failure of conventional therapies, 6 cycles of gemcitabine treatment produced partial remission of cutaneous lesions and stable disease throughout a 12-month follow-up period, suggesting that gemcitabine is a promising chemotherapeutic agent for refractory mycosis fungoides.
- Find related publications in this database (using NLM MeSH Indexing)
- Antimetabolites, Antineoplastic - administration and dosage
- Biopsy, Needle - administration and dosage
- Deoxycytidine - administration and dosage
- Dose-Response Relationship, Drug - administration and dosage
- Drug Administration Schedule - administration and dosage
- Female - administration and dosage
- Follow-Up Studies - administration and dosage
- Granuloma - pathology
- Humans - pathology
- Immunohistochemistry - pathology
- Infusions, Intravenous - pathology
- Middle Aged - pathology
- Mycosis Fungoides - diagnosis
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- Treatment Outcome - diagnosis
- Find related publications in this database (Keywords)
- cutaneous lymphoma
- chemotherapy
- cytotoxic proteins
- gemcitabine
- granulomatous mycosis fungoides