Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Scarabello, A; Leinweber, B; Ardigó, M; Rütten, A; Feller, AC; Kerl, H; Cerroni, L.
Cutaneous lymphomas with prominent granulomatous reaction: a potential pitfall in the histopathologic diagnosis of cutaneous T- and B-cell lymphomas.
Am J Surg Pathol. 2002; 26(10):1259-1268
Doi: 10.1097%2F00000478-200210000-00002
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- Führende Autor*innen der Med Uni Graz
- Cerroni Lorenzo
- Co-Autor*innen der Med Uni Graz
- Kerl Helmut
- Leinweber Bernd
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- Abstract:
- The presence of a granulomatous reaction in lesions of cutaneous lymphomas has been described in the past in several cases. Especially in mycosis fungoides, a "granulomatous" variant of the disease has been well characterized. We studied the clinicopathologic features of cutaneous lymphomas with prominent granulomatous reaction, including both cutaneous T-cell lymphomas and B-cell lymphomas (primary cutaneous lymphoma 22, secondary cutaneous lymphoma one). Biopsies of 23 patients with histopathologic features of cutaneous T-cell lymphoma or cutaneous B-cell lymphoma with prominent granulomatous reaction were included in this study. A prominent granulomatous reaction was defined as the presence of a granulomatous component exceeding 25% of the dermal infiltrate. There were 14 cases of mycosis fungoides, two of subcutaneous panniculitis-like T-cell lymphoma, four of small/medium pleomorphic T-cell lymphoma, one of follicle center cell lymphoma, one of large B-cell lymphoma, and one of secondary cutaneous peripheral T-cell lymphoma. Altogether, a prominent granulomatous reaction could be observed in 1.8% of all patients with cutaneous lymphoma (primary or secondary) registered in the files of the Department of Dermatology of the University of Graz (Graz, Austria), demonstrating that there is a distinct, albeit small, proportion of cases revealing this peculiar reaction pattern. In seven cases a misdiagnosis of granulomatous dermatitis preceded the correct diagnosis for a period of 1-216 months, suggesting that sequential biopsies and complete phenotypic and molecular genetic analyses should be carried out in cases of "unusual" granulomatous dermatitis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Diagnosis, Differential -
- Female -
- Humans -
- Lymphoma, B-Cell - immunology
- Lymphoma, T-Cell, Cutaneous - immunology
- Male - immunology
- Middle Aged - immunology
- Mycosis Fungoides - pathology
- Skin Neoplasms - immunology
- Find related publications in this database (Keywords)
- granulomatous lymphoma
- cutaneous T-cell lymphoma
- cutaneous B-cell lymphoma