Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Legat, FJ; Griesbacher, T; Schicho, R; Althuber, P; Schuligoi, R; Kerl, H; Wolf, P.
Repeated subinflammatory ultraviolet B irradiation increases substance P and calcitonin gene-related peptide content and augments mustard oil-induced neurogenic inflammation in the skin of rats.
Neurosci Lett. 2002; 329(3):309-313
Doi: 10.1016/S0304-3940(02)00428-7
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- Führende Autor*innen der Med Uni Graz
- Legat Franz
- Co-Autor*innen der Med Uni Graz
- Griesbacher Thomas
- Kerl Helmut
- Schicho Rudolf
- Schuligoi Rufina
- Wolf Peter
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- Abstract:
- The cutaneous neurosensory system is suggested to be involved in the pathophysiology of pruritus and skin diseases such as psoriasis. We investigated if repeated subinflammatory doses of ultraviolet B (UVB) irradiation similar to those used to treat pruritus or psoriasis would affect the cutaneous neurosensory system. Sprague-Dawley rats were irradiated thrice weekly for 2-4 weeks with subinflammatory doses of UVB. Three days after the last UVB exposure: (i), the skin contents of substance P (SP), calcitonin gene-related peptide (CGRP), and nerve growth factor (NGF) were quantified; (ii), the skin nerve fiber density was observed; and (iii), the effect of UVB on mustard oil-induced neurogenic inflammation was determined. UV exposure significantly increased SP and CGRP content and mustard oil-induced neurogenic inflammation in UV-irradiated but not non-irradiated skin; however, it did not affect cutaneous NGF content or overall nerve fiber density. These data suggest that repeated subinflammatory UVB irradiation locally increases the content of cutaneous SP and CGRP by an increase of neuropeptide content of nerve fibers rather than by an increase of overall nerve fiber density.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcitonin Gene-Related Peptide - metabolism
- Female -
- Mustard Plant -
- Nerve Fibers - drug effects
- Nerve Fibers - radiation effects
- Neurogenic Inflammation - chemically induced
- Neurogenic Inflammation - metabolism
- Neurogenic Inflammation - pathology
- Neurons, Afferent - drug effects
- Neurons, Afferent - metabolism
- Neurons, Afferent - radiation effects
- Plant Extracts -
- Plant Oils -
- Rats -
- Rats, Sprague-Dawley -
- Skin - innervation
- Skin - pathology
- Skin - radiation effects
- Substance P - metabolism
- Ultraviolet Rays -
- Find related publications in this database (Keywords)
- neuropeptide
- nerve growth factor
- sensory nerve fiber
- rat skin
- ultraviolet B
- chronic ultraviolet exposure