Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Basten, O; Bandorski, D; Langner, C.
Hemangiosarcoma of the liver with unusual expression of neuron-specific enolase (NSE)
Z Gastroenterol. 2002; 40(8):577-580
Doi: 10.1055/s-2002-33415
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Langner Cord
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- A 68-year-old male patient presented with unspecific decline of general health, multiple tumours in the liver discovered by ultrasound examination and a focus suggestive of tumour on chest x-ray. He was hospitalised because of suspected metastatic lung carcinoma. Laboratory analysis revealed a distinct elevation of serum neuron-specific enolase (NSE, 26,1 micro g/l). A CT scan of the abdomen confirmed the presence of multiple tumour foci in both hepatic lobes, while the lung, however, was found to be free of tumour on CT-examination. Bronchoscopy, gastroduodenoscopy and colonoscopy were unremarkable. Subsequently, an ultrasound guided fine-needle biopsy of the liver was performed. Histological examination disclosed hemangiosarcoma with unusual, though unequivocal expression of NSE in tumour cells. As even follow-up examinations were unable to trace out any extrahepatic primary tumour, the hemangiosarcoma was concluded to be of hepatic origin. The patient succumbed to his disease 6 months later, an autopsy was not performed. This case report of a NSE-producing primary hemangiosarcoma of the liver clearly outlines that a histological confirmation of an allegedly clear clinical diagnosis should always be performed because malignant tumours are capable of (co-)expressing so called tumour markers independently of their histogenesis.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Biopsy -
- Diagnosis, Differential -
- Fatal Outcome -
- Follow-Up Studies -
- Hemangiosarcoma - pathology
- Humans - pathology
- Liver - pathology
- Liver Neoplasms - pathology
- Male - pathology
- Phosphopyruvate Hydratase - analysis
- Tumor Markers, Biological - analysis
- Find related publications in this database (Keywords)
- hemangiosarcoma
- liver
- tumour markers
- neuron-specific enolase