Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kostner, KM; Kostner, GM.
Lipoprotein(a): still an enigma?
Curr Opin Lipidol. 2002; 13(4):391-396
Doi: 10.1097%2F00041433-200208000-00006
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Kostner Gerhard
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- Abstract:
- PURPOSE OF REVIEW: Lipoprotein(a) belongs to the class of the most atherogenic lipoproteins. Despite intensive research - in the last year more than 80 papers have been published on this topic - information is still lacking on the physiological function of lipoprotein(a) and the site of its catabolism. Important advances have been made in the knowledge of these points, which may have some therapeutic implications. RECENT FINDINGS: The association of high lipoprotein(a) values with an increase in risk for coronary events has been documented in further prospective studies. This increased risk may relate to recent findings that apolipoprotein(a) is produced in situ within the vessel wall. In addition, lipoprotein(a) binds and inactivates the tissue factor pathway inhibitor and induces plasminogen activator inhibitor type 2 expression in monocytes. A new antisense oligonucleotide strategy has been proposed which efficiently inhibits apolipoprotein(a) expression in vitro and in vivo. Apolipoprotein(a), however, suppresses angiogenesis and thus may interfere with the infiltration of tumor cells. Finally, the enzymatic activity leading to the formation of apolipoprotein(a) fragments in plasma and their catabolism have been further elucidated. SUMMARY: We are still far away from understanding the pathways involved in lipoprotein(a) catabolism, and the physiological function of this lipoprotein. Recent findings, however, provide new insight into pathomechanisms in patients with increased lipoprotein(a) related to hemostasis, which may serve as a basis for designing new treatment strategies.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Arteriosclerosis - blood
- Endothelium - cytology
- Hemostasis - cytology
- Humans - cytology
- Kidney - metabolism
- Lipoprotein(a) - blood
- Risk Factors - blood
- Find related publications in this database (Keywords)
- tissue factor pathway inhibitor
- antisense oligonucleotides
- angiogenesis