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Selected Publication:
Vergnaud, P; Lunt, M; Scheidt-Nave, C; Poor, G; Gennari, C; Hoszowski, K; Vaz, AL; Reid, DM; Benevolenskaya, L; Grazio, S; Weber, K; Miazgowski, T; Stepan, JJ; Masaryk, P; Galan, F; Armas, JB; Lorenc, R; Havelka, S; Perez Cano, R; Seibel, M; Armbrecht, G; Kaptoge, S; O'Neill, TW; Silman, AJ; Felsenberg, D; Reeve, J; Delmas, PD.
Is the predictive power of previous fractures for new spine and non-spine fractures associated with biochemical evidence of altered bone remodelling? The EPOS study. European Prospective Osteoporosis Study.
Clin Chim Acta. 2002; 322(1-2):121-132
Doi: 10.1016%2FS0009-8981%2802%2900164-X
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- Weber Kurt
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- Abstract:
- BACKGROUND: In the European Prospective Osteoporosis Study (EPOS), a past spine fracture increased risk of an incident fracture 3.6 - 12-fold even after adjusting for BMD. We examined the possibility that biochemical marker levels were associated with this unexplained BMD-independent element of fracture risk. METHODS: Each of 182 cases in EPOS of spine or non-spine fracture that occurred in 3.8 years of follow-up was matched by age, sex and study centre with two randomly assigned never-fractured controls and one case of past fracture. Analytes measured blind were: osteocalcin, bone-specific alkaline phosphatase, total alkaline phosphatase, serum creatinine, calcium, phosphate and albumin, together with the collagen cross-links degradation products serum CTS and urine CTX. Most subjects also had bone density measured by DXA. RESULTS: Cases who had recent fractures did not differ in marker levels from cases who had their last fracture more than 3 years previously. No statistically significant effect of recent fracture was found for any marker except osteocalcin, which was 17.6% lower in recent peripheral cases compared to unfractured controls (p<0.05) and this was independent of BMD. CONCLUSION: Past fracture as a risk indicator for future fracture is not strongly mediated through increased bone turnover.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aging -
- Alkaline Phosphatase - metabolism
- Biological Markers - analysis
- Bone Density - physiology
- Bone Remodeling - physiology
- Calcium - analysis
- Collagen - metabolism
- Creatinine - blood
- Female - blood
- Follow-Up Studies - blood
- Fractures, Bone - complications
- Humans - complications
- Male - complications
- Matched-Pair Analysis - complications
- Middle Aged - complications
- Osteocalcin - analysis
- Phosphates - analysis
- Prognosis - analysis
- Recurrence - analysis
- Sex Characteristics - analysis
- Spinal Fractures - complications
- Vitamin D - analysis
- Find related publications in this database (Keywords)
- osteoporosis
- fractures
- biochemical markers
- bone turnover
- epidemiology
- bone densitometry