Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Langner, C; Rupar, G; Leibl, S; Hutterer, G; Chromecki, T; Hoefler, G; Rehak, P; Zigeuner, R.
Alpha-methylacyl-CoA racemase (AMACR/P504S) protein expression in urothelial carcinoma of the upper urinary tract correlates with tumour progression.
Virchows Arch. 2006; 448(3):325-330
Doi: 10.1007/s00428-005-0129-6
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- Führende Autor*innen der Med Uni Graz
- Langner Cord
- Co-Autor*innen der Med Uni Graz
- Chromecki Thomas
- Höfler Gerald
- Hutterer Georg
- Leibl Sebastian
- Rehak Peter
- Zigeuner Richard
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- Abstract:
- Alpha-methylacyl-CoA racemase (AMACR/P504S) is a useful biomarker of prostate cancer. We evaluated the expression of AMACR in upper urinary tract urothelial carcinomas with respect to associations with tumour stage, grade and metastasis-free survival. A total of 268 tumours were investigated immunohistochemically using a tissue microarray technique. AMACR expression was noted in 127 of 261 (48.7%) evaluated tumours and was associated with high tumour stage [58 of 139 (41.7%) pTa/pT1 vs. 69 of 122 (56.6%) pT2-pT4, P=0.019] and high tumour grade [44 of 137 (32.1%) low vs. 83 of 124 (66.9%) high grade, P<0.001]. In addition, AMACR expression was associated with the presence of tumour necrosis (P<0.001) and marked stromal desmoplasia (P=0.0026). This correlation indicates that increased AMACR expression might be related to hypoxia-induced changes in cancer cell metabolism, such as increased dependence on fatty acid oxidation for energy generation. Progressive disease was observed in 73 of 183 (39.9%) patients with solitary invasive carcinomas and was associated with AMACR expression (P=0.017). Multivariate analysis, however, proved only pT-stage >1 (P<0.001) and high tumour grade (P<0.001) to be independent predictors of patient outcome. In conclusion, AMACR expression correlated with advanced tumour stage and grade and may serve as an additional prognostic indicator in upper urinary tract urothelial cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Transitional Cell - enzymology Carcinoma, Transitional Cell - metabolism Carcinoma, Transitional Cell - pathology
- Disease-Free Survival -
- Female -
- Humans -
- Kidney Neoplasms - enzymology Kidney Neoplasms - mortality Kidney Neoplasms - pathology
- Male -
- Middle Aged -
- Proportional Hazards Models -
- Racemases and Epimerases - metabolism
- Survival Rate -
- Tumor Markers, Biological - metabolism
- Ureteral Neoplasms - enzymology Ureteral Neoplasms - mortality Ureteral Neoplasms - pathology
- Find related publications in this database (Keywords)
- urothelial carcinoma
- transitional cell carcinoma
- upper urinary tract
- alpha-methylacyl-CoA racemase (AMACR)
- prognosis