Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Homann, CN; Wenzel, K; Kriechbaum, N; Suppan, K; Crevenna, R; Ivanic, G; Dressler, D.
Botulinum toxin--the dose controls the poison. A historical sketch
Nervenarzt. 2002; 73(6):519-524
Doi: 10.1007/s00115-002-1305-4
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- Führende Autor*innen der Med Uni Graz
- Homann Carl
- Co-Autor*innen der Med Uni Graz
- Kriechbaum Norbert
- Suppan Klaudia
- Wenzel Karoline
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- Abstract:
- Botulism, a potentially lethal form of paralytic food poisoning, was described as early as 1793. Basic research, especially in the late nineteenth and early twentieth centuries, revealed that botulism is caused by exotoxins. Further biochemical work around and after the Second World War gave insight into the molecular structure of seven different serotypes of botulinum toxin (BT/A-G) as well as into its acetylcholine blocking mode of action. In 1977, Scott treated patients with strabism by injecting minute amounts of purified BT/A. In short sequence, BT proved effective in blepharospasm, cervical dystonia, and various off-label indications. In the near future, registration of these new indications, marketing of new serotypes (BT/B), and availability of more practical antibody tests can be expected. The first applications of BT were performed by Roggenkaemper, Dressler, and Benecke in Germany and by Poewe and Auff in Austria. According to a worldwide trend, a rapid expansion regarding BT users and indications followed. Formation of BT competence centers in both countries aims at maintaining high standards in BT research and education.
- Find related publications in this database (using NLM MeSH Indexing)
- Austria -
- Botulinum Toxin Type A - administration and dosage
- Botulinum Toxins - history
- Botulism - history
- Dose-Response Relationship, Drug - history
- Germany - history
- History, 18th Century - history
- History, 19th Century - history
- History, 20th Century - history
- Humans - history
- Injections, Intramuscular - history
- Nervous System Diseases - drug therapy
- Find related publications in this database (Keywords)
- botulinum toxin
- historical review
- development in Germany
- development in Austria
- future perspectives