Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Weger, M; Stanger, O; Deutschmann, H; Leitner, FJ; Renner, W; Schmut, O; Semmelrock, J; Haas, A.
The role of hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in patients with retinal artery occlusion.
Am J Ophthalmol. 2002; 134(1):57-61
Doi: 10.1016%2FS0002-9394%2802%2901471-X
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- Führende Autor*innen der Med Uni Graz
- Weger Martin
- Co-Autor*innen der Med Uni Graz
- Deutschmann Hannes
- Haas Anton
- Renner Wilfried
- Schmut Otto
- Semmelrock Hans-Jürgen
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- Abstract:
- PURPOSE: Hyperhomocysteinemia has been established as an important risk factor for cardiovascular diseases. The aim of the present study was to investigate whether hyperhomocysteinemia and/or homozygosity for the methylenetetrahydrofolate reductase (MTHFR) C677T mutation are associated with an increased risk for retinal artery occlusion (RAO). DESIGN: Retrospective case-control study. METHODS: We studied 105 consecutive patients with retinal artery occlusion and 105 age and sex-matched control subjects. Fasting plasma homocysteine levels were determined by high-performance liquid chromatography, while genotypes of the MTHFR C677T mutation were determined by polymerase chain reaction. RESULTS: Mean plasma homocysteine levels were significantly higher in patients with RAO compared with control subjects (12.2 +/- 4.8 micromol/l vs 10.3 +/- 3.4 micromol/l; P =.003). Hyperhomocysteinemia was defined by the 95th percentile of control plasma homocysteine levels as 15.8 micromol/l. Twenty (19.1%) patients with RAO exceeded this level and were therefore classified as hyperhomocysteinemic compared with 5 (4.8%) control subjects (P =.003). The odds ratio for these patients was calculated at 4.7 (95% confidence interval [CI], 1.5-15.1). Mean plasma folate levels were significantly lower in patients than in the control group (5.6 +/- 2.3 ng/ml vs. 6.3 +/- 2.5 ng/ml; P =.04). The prevalence of the homozygous genotype of methylenetetrahydrofolate reductase C677T mutation did not significantly differ between patients and controls. CONCLUSIONS: Our results suggest that hyperhomocysteinemia, but not homozygosity, for the MTHFR C677T mutation is associated with RAO.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Case-Control Studies -
- Chromatography, High Pressure Liquid -
- DNA - analysis
- Female - analysis
- Genotype - analysis
- Homocysteine - blood
- Humans - blood
- Hyperhomocysteinemia - blood
- Male - blood
- Methylenetetrahydrofolate Reductase (NADPH2) - blood
- Middle Aged - blood
- Oxidoreductases Acting on CH-NH Group Donors - genetics
- Point Mutation - genetics
- Polymerase Chain Reaction - genetics
- Retinal Artery Occlusion - blood
- Retrospective Studies - blood
- Risk Factors - blood