Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Greinix, HT; Nachbaur, D; Krieger, O; Eibl, M; Knöbl, P; Kalhs, P; Lutz, D; Linkesch, W; Niederwieser, D; Hinterberger, W; Lechner, K; Rosenmayr, A; Gritsch, B.
Factors affecting long-term outcome after allogeneic haematopoietic stem cell transplantation for acute myelogenous leukaemia: a retrospective study of 172 adult patients reported to the Austrian Stem Cell Transplantation Registry.
Br J Haematol. 2002; 117(4):914-923
Doi: 10.1046/j.1365-2141.2002.03532.x
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- Führende Autor*innen der Med Uni Graz
- Greinix Hildegard
- Co-Autor*innen der Med Uni Graz
- Eibl Margit
- Linkesch Werner
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- Abstract:
- Between 1982 and 2000, 172 patients with acute myelogenous leukaemia (AML) received haematopoietic stem cell transplants (SCT) from related (n = 132) or unrelated (n = 40) donors at four Austrian transplant centres and their results were reported to the Austrian Stem Cell Transplantation Registry. Conditioning for SCT consisted of cyclophosphamide and total body irradiation in 156 (91%) patients. Graft-versus-host disease (GVHD) prophylaxis was with standard cyclosporine and methotrexate in 95 (55%) patients. Median post-transplant follow-up was 5.6 years (range, 0.2--16.7). Multivariate analysis of transplant-related mortality (TRM) identified four variables associated with a lower risk: disease status of first complete remission (CR) at SCT, patient age of 45 years and younger, transplant performed during or after 1995, and lack of acute GVHD. Variables associated with significantly improved leukaemia-free survival were: bone marrow as the stem cell source, disease status of first CR at SCT, and occurrence of chronic GVHD. In multivariate analysis, transplantation performed during or after 1995, first CR at SCT, occurrence of limited chronic GVHD and lack of acute GVHD grades III to IV were associated with increased overall survival. Based on these analyses, options for the improvement of results obtained with allogeneic SCT in patients with AML could be defined.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age Factors -
- Cyclosporine - therapeutic use
- Female -
- Graft vs Host Disease - prevention & control
- Hematopoietic Stem Cell Transplantation - mortality
- Humans -
- Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - surgery
- Male -
- Methotrexate - therapeutic use
- Methylprednisolone - therapeutic use
- Middle Aged -
- Multivariate Analysis -
- Registries -
- Retrospective Studies -
- Risk Factors -
- Survival Rate -
- Transplantation Conditioning -
- Transplantation, Homologous -
- Treatment Outcome -
- Whole-Body Irradiation -
- Find related publications in this database (Keywords)
- acute myelogenous leukaemia
- allogeneic stem cell transplantation