Medizinische Universität Graz - Research portal
Selected Publication:
Ferenci, P; Zollner, G; Trauner, M.
Hepatic transport systems.
J Gastroenterol Hepatol. 2002; 17 Suppl(6):S105-S112
Doi: 10.1046/j.1440-1746.17.s1.15.x
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Trauner Michael
- Zollner Gernot
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- Abstract:
- The identification of the genes responsible for various genetic liver disorders lead to a better understanding of basic physiology of hepatic transport systems. In this review we focus on transport systems involved in the generation of bile and in the maintenance of copper homeostasis. Abnormal function of these transporters results in diseases like Wilson's disease, progressive familial cholestasis syndromes, Dubin-Johnson syndrome and cystic fibrosis. Beyond these well defined diseases, functional impairments of transport proteins may predispose to non-genetic diseases ranging from intrahepatic cholestasis of pregnancy to neurodegenerative disorders including Alzheimer's disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenosine Triphosphatases - metabolism
- Bile - secretion
- Biological Transport -
- Cation Transport Proteins - metabolism
- Cholestasis, Intrahepatic - genetics Cholestasis, Intrahepatic - metabolism
- Copper - metabolism
- Cystic Fibrosis - genetics
- Humans -
- Liver - metabolism