Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wieland, A; Kerbl, R; Berghold, A; Schwinger, W; Mann, G; Urban, C.
C-reactive protein (CRP) as tumor marker in pediatric and adolescent patients with Hodgkin disease.
Med Pediatr Oncol. 2003; 41(1):21-25
Doi: 10.1002/mpo.10286
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Kerbl Reinhold
- Co-Autor*innen der Med Uni Graz
- Berghold Andrea
- Schwinger Wolfgang
- Urban Ernst-Christian
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- Abstract:
- BACKGROUND: C-reactive protein (CRP) is an acute phase protein produced in the liver. An elevated CRP is a nonspecific marker of inflammation. Additionally, it also appears to be a prognostic marker in several malignancies. Elevated CRP levels in adult patients with Hodgkin disease (HD) were reported previously. However, levels of CRP have not been evaluated in pediatric and adolescent HD patients. PROCEDURE: We analyzed CRP serum levels in 95 consecutive pediatric and adolescent patients with Hodgkin disease. CRP levels were correlated with stage, absence or presence of B symptoms, and prognosis. RESULTS: At the time of diagnosis increased serum CRP levels were found in 64 % (61/95) of the patients with a median of 21 mg/L (range: <5-211). Serum C-reactive protein levels correlated with stage and were higher in patients with B symptoms. Higher CRP levels were associated with an increased risk of relapse. CONCLUSION: In addition to soluble interleukin 2 receptor (sIL-2R) levels, CRP holds promise as a diagnostic and prognostic index and follow-up monitor in pediatric and adolescent patients with Hodgkin disease, and merits further investigation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Austria -
- C-Reactive Protein - analysis
- Child - analysis
- Child, Preschool - analysis
- Female - analysis
- Hodgkin Disease - blood
- Humans - blood
- Male - blood
- Neoplasm Staging - blood
- Predictive Value of Tests - blood
- Prognosis - blood
- Sensitivity and Specificity - blood
- Tumor Markers, Biological - blood
- Find related publications in this database (Keywords)
- C-reactive protein
- Hodgkin disease
- cancer in childhood and adolescence
- tumor marker
- prognostic index