Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Zweiker, R; Stoschitzky, K; Maier, R; Klein, W.
Efficiency and safety of ACE-inhibiting imidapril in patients with essential hypertension
Acta Med Austriaca. 2002; 29(2):72-76
Doi: 10.1046%2Fj.1563-2571.2002.02007.x
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Zweiker Robert
- Co-Autor*innen der Med Uni Graz
- Maier Robert
- Stoschitzky Kurt
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- Abstract:
- In a survey including 2224 patients with essential hypertension we investigated efficacy and tolerability of the new ACE-inhibitor Imidapril. Mean blood pressure at baseline was 172 +/- 19/98 +/- 10 mmHg. Treatment with Imidapril 5-20 mg once daily caused a decrease in BP by 21 +/- 17/11 +/- 10 mmHg (p < 0.01/0.01). Systolic BP was reduced by > 15 mmHg in 71% diastolic BP by > 10 mmHg in 64% of patients. 29% of patients achieved the treatment goal of a blood pressure < or = 140/90 within an average of 26 days. Imidapril decreased pulse-pressure (one of the most important risk markers in hypertension) by 18% (74 +/- 17 to 61 +/- 11 mmHg, p < 0.01). ACE-inhibitor related adverse effects (cough, vertigo, headache, pruritus, tachycardia, orthostatic dysregulation or nausea) were observed in 38 patients (< 2%). Efficacy of treatment was graded by the physician in charge of the patient care by means of a questionnaire. Gradings were excellent or good in 96% of patients, moderate in 3% and poor in < 1%. In summary, the effects of Imidapril on blood pressure were comparable to those of other ACE-inhibitors. However, the frequency of adverse effects was low and similar to that of angiotensin-II-antagonists.
- Find related publications in this database (using NLM MeSH Indexing)
- Angiotensin-Converting Enzyme Inhibitors - adverse effects
- Blood Pressure - drug effects
- Diastole - drug effects
- Humans - drug effects
- Hypertension - drug therapy
- Imidazoles - adverse effects
- Imidazolidines - adverse effects
- Pulse - adverse effects
- Questionnaires - adverse effects
- Reproducibility of Results - adverse effects
- Systole - drug effects
- Find related publications in this database (Keywords)
- ACE-inhibitor
- hypertension
- adverse effects
- survey