Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Dong, H; Kerl, H; Cerroni, L.
EMLA cream-induced irritant contact dermatitis.
J Cutan Pathol. 2002; 29(3):190-192
Doi: 10.1034%2Fj.1600-0560.2002.290312.x
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Cerroni Lorenzo
- Co-Autor*innen der Med Uni Graz
- Kerl Helmut
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- Abstract:
- BACKGROUND: The Eutectic Mixture of Local Anesthetics (EMLA cream) is a topical anesthetic used for providing pain relief in patients undergoing superficial surgical procedures. Cutaneous side-effects have been reported rarely. CASE REPORT: We present a case of irritant contact dermatitis induced by EMLA cream in a 6-year-old boy with Wiskott-Aldrich syndrome. Our patient showed clinically a well circumscribed patch corresponding to the site of application of the topical anesthetic. Histopathology showed confluent necrosis of keratinocytes in the upper epidermis, a mixed inflammatory infiltrate with priminent neutrophils in the upper dermis, and focal signs of interface changes including basal cell vacuolization and subepidermal cleft formation. CONCLUSIONS: Graft-vs.-host-disease (GVHD), necrolytic migratory erythema, dermatitis enteropathica and pellagra should be considered in the histopathologic differential diagnosis of acute contact dermatitis caused by EMLA.
- Find related publications in this database (using NLM MeSH Indexing)
- Acrodermatitis -
- Administration, Topical -
- Anesthetics, Local - administration and dosage
- Child - administration and dosage
- Dermatitis, Contact - etiology
- Diagnosis, Differential - etiology
- Drug Eruptions - diagnosis
- Erythema - diagnosis
- Graft vs Host Disease - diagnosis
- Humans - diagnosis
- Irritants - adverse effects
- Keratinocytes - drug effects
- Lidocaine - administration and dosage
- Male - administration and dosage
- Necrosis - administration and dosage
- Pellagra - chemically induced
- Prilocaine - administration and dosage