Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mazza, E; Nava, A; Bauer, M; Winter, R; Bajka, M; Holzapfel, GA.
Mechanical properties of the human uterine cervix: an in vivo study.
Med Image Anal. 2006; 10(2):125-136
Doi: 10.1016/j.media.2005.06.001
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Holzapfel-Bauer Margit
- Winter Raimund
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Experimental results of in vivo measurements to characterize the mechanical behaviour of human uterine cervices are documented. Aspiration experiments were performed on eight uteri in vivo, before vaginal/abdominal hysterectomy, and four uteri were also tested ex vivo, approximately 1.5h after extraction. The reproducibility of the mechanical data from the in vivo aspiration experiments has been analysed. For an introduced "stiffness parameter" the organ specific SD is 22%, so that the proposed experimental procedure allows detections of 30% changes with respect to a reference value of the stiffness parameter. A comparison of in vivo and ex vivo data from the same organ has shown that: (i) the ex vivo mechanical response of the uterine cervix tissue does not differ considerably from that observed in vivo; (ii) some differences can be identified in tissue pre-conditioning with ex vivo showing a stronger history dependence with respect to in vivo; (iii) the differences in the time dependence of the mechanical response are not significant and might be masked by the variability of the measured data. This study represents a first step of a clinical application aiming at analysing the mechanical response of normal cervical tissue at different gestational ages, and identifying the mechanical properties that characterize pathologic conditions such as cervical insufficiency leading to preterm delivery.
- Find related publications in this database (using NLM MeSH Indexing)
- Biomechanics - instrumentation
- Cervix Uteri - anatomy and histology
- Computer Simulation - anatomy and histology
- Elasticity - anatomy and histology
- Equipment Design - anatomy and histology
- Equipment Failure Analysis - anatomy and histology
- Female - anatomy and histology
- Hardness - anatomy and histology
- Humans - anatomy and histology
- Models, Biological - anatomy and histology
- Physical Stimulation - instrumentation
- Stress, Mechanical - instrumentation
- Vacuum - instrumentation
- Find related publications in this database (Keywords)
- uterine cervix
- preterm delivery
- in vivo experiment
- aspiration device
- image analysis
- constitutive modelling
- mechanical properties