Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wurzinger, S; Bratu, M; Wonisch, W; Wintersteiger, R; Halwachs-Baumann, G; Porta, S.
Interdependency of the oxidizability of lipoproteins and peroxidase activity with base excess, HCO3, pH and magnesium in human venous and capillary blood.
Life Sci. 2006; 78(15):1754-1759
Doi: 10.1016/j.lfs.2005.08.010
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Porta Sepp
- Co-Autor*innen der Med Uni Graz
- Baumann Gabriele
- Wonisch Willibald
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- Abstract:
- As continuous production of free radicals and reactive oxygen species is a normal metabolic process, increased metabolism during exercise/workload should increase free radical generation and oxidative stress. Oxidative stress intensity should then depend on the intensity of metabolic stress effects. Intensity of stress is usually reflected in norepinephrine (NE) levels, which correlate linearly and significantly with changes in blood gases, blood buffer systems, blood electrolytes, blood glucose and lactate [Porta, S., Leitner, G., Heidinger, D., Lang, T., Weiss, U., Smolle, K.H., Hasiba, K., 1997. Magnesium während der Alpinausbildung bringt um 30% bessere Energieverwertung. Magnesium-Bulletin 19(2), 59-61]. Those parameters were used in an open study design to screen 64 subjects for metabolic stress effects along with their antioxidative capacity using both venous and capillary blood. To compare venous and capillary blood, we took venous blood samples from 12 healthy volunteers and capillary blood from 52 other healthy subjects. To show whether free radical changes indeed go along with metabolic stress effects, we tried to quantify relations between metabolic stress effects and oxidative stress by linear correlations. In conclusion, both venous and capillary blood are suitable for determining at least those parameters of the oxidative state that we used. All significant correlations of peroxidase activity and oxidation lag time (OLT) with pH, bicarbonate (HCO3), base excess (BE) and magnesium (Mg) indicate that free radical production increases with metabolism. Those relationships could help to evaluate the oxidative state more precisely.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Antioxidants - metabolism
- Bicarbonates - blood
- Blood Gas Analysis -
- Blood Glucose - analysis
- Capillaries -
- Female -
- Humans -
- Hydrogen-Ion Concentration -
- Lipoproteins - blood
- Magnesium - blood
- Male -
- Middle Aged -
- Oxidative Stress -
- Peroxidase - blood
- Potassium - blood
- Veins -
- Find related publications in this database (Keywords)
- venous blood
- capillary blood
- peroxidase activity
- oxidation lag time measurement