Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Renner, W; Brodmann, M; Pabst, E; Stanger, O; Wascher, TC; Pilger, E.
The V34L polymorphism of factor XIII and peripheral arterial disease.
Int Angiol. 2002; 21(1):53-57
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Renner Wilfried
- Co-Autor*innen der Med Uni Graz
- Brodmann Marianne
- Pilger Ernst
- Wascher Thomas
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- Abstract:
- BACKGROUND: Factor XIII catalyzes crosslinking of fibrin in the last steps of the coagulation process. A common polymorphism in the gene for factor XIII A subunit (F13A1 V34L) has been associated with a decreased risk for coronary artery disease, cerebrovascular disease, and deep venous thrombosis. METHODS: To analyze the role of this polymorphism in peripheral arterial disease (PAD) we performed a case-control study including 873 patients with documented PAD and a total of 523 controls without vascular disease. The F13A1 genotype was determined by an allele-specific polymerase chain reaction. RESULTS: Genotype distribution and allele frequencies were not significantly different between patients (VV: 51.9%; VL: 40.7%; LL: 7.4%) and controls (VV: 54.7%; VL: 39.2%; LL: 6.1%). Mean age at onset of the disease was significantly higher in LL homozygous subjects than in VV homozygous subjects (67.3 versus 64.1 years, p=0.017). Heterozygous subjects had an intermediate age at onset (65.1 years), suggesting a gene-dose effect. The association of the L34 variant with onset of PAD remained significant after adjustment for other risk factors. The effect was stronger in men than in women. CONCLUSIONS: We conclude that the F13A1 V34L polymorphism was not associated with the presence of PAD in our study, but may be linked to a later onset of the disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Alleles -
- Ankle - physiopathology
- Austria - epidemiology
- Case-Control Studies - epidemiology
- Coronary Arteriosclerosis - complications
- Factor XIII - genetics
- Female - genetics
- Genotype - genetics
- Humans - genetics
- Leg - blood supply
- Male - blood supply
- Middle Aged - blood supply
- Peripheral Vascular Diseases - complications
- Polymorphism, Genetic - physiology
- Risk Factors - physiology
- Ultrasonography, Doppler - physiology
- Venous Thrombosis - complications
- Find related publications in this database (Keywords)
- atherosclerosis
- peripheral vascular diseases
- genetics
- blood coagulation
- factor XIII