Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Domej, W; Tilz, GP; Földes-Papp, Z; Demel, U; Rabold, T; Holzer, H.
Cystatin C of pleural effusion as a novel diagnostic aid in pleural diseases of different aetiologies.
Clin Sci (Lond). 2002; 102(3):373-380
Doi: 10.1042%2FCS20010168
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- Führende Autor*innen der Med Uni Graz
- Domej Wolfgang
- Tilz Gernot
- Co-Autor*innen der Med Uni Graz
- Demel Ulrike
- Földes-Papp Zeno
- Holzer Herwig
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- Abstract:
- There has been considerable recent interest in the potential use of serum cystatin C as a diagnostic tool. Here we examined the hypothesis that the cystatin C level in the pleural effusion can differ from the corresponding serum level. We evacuated pleural effusion fluids from 47 patients by thoracentesis. Cystatin C, beta(2)-microglobulin, inorganic phosphate, creatinine and total protein were quantified in both pleural effusion fluids and corresponding sera. We determined cystatin C levels in pleural effusions and calculated the ratio of cystatin C levels in serum and effusion, to discriminate between effusions caused by severe renal impairment and other types of effusion. Extremely high concentrations of cystatin C in serum/effusion pairs were only measured in patients with renal failure (6.0 +/- 0.8/6.0 +/- 0.8 mg/l, means +/- S.D., n=11). A clearly defined region was found to correspond to pleural effusion caused by renal failure (r=0.954). The quantification of cystatin C in the effusion was justified by the discovery that there were some patients with a high serum cystatin C level but a low effusion concentration, or a low serum cystatin C but a high effusion concentration, indicating causes other than renal failure. In conclusion, the pilot data indicate a relationship between the cystatin C concentration in pleural fluid and the underlying disease. Thus cystatin C levels in pleural effusion and serum may be a valuable criterion for the differential diagnosis of pleural diseases of different aetiologies.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Biological Markers - analysis
- Creatinine - analysis
- Cystatins - analysis
- Diagnosis, Differential - analysis
- Female - analysis
- Heart Failure - metabolism
- Humans - metabolism
- Kidney Failure - metabolism
- Liver Cirrhosis - metabolism
- Male - metabolism
- Middle Aged - metabolism
- Phosphates - analysis
- Pleural Diseases - diagnosis
- Pleural Effusion - metabolism
- Pleural Effusion, Malignant - metabolism
- Proteins - analysis
- beta 2-Microglobulin - analysis
- Find related publications in this database (Keywords)
- cystatin C
- pleural disease
- pleural effusion