Medizinische Universität Graz - Research portal
Selected Publication:
Vrecko, K; Pfragner, R; Siegl, V; Schauenstein, K; Reibnegger, G.
Effect of interferon-gamma and LPS on tetrahydrobiopterin in rat PC 12 and human KNA cells
PTERIDINES 2001 12: 167-171.
Doi: 10.1515/pteridines.2001.12.4.167
Web of Science
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Vrecko Karoline
- Co-authors Med Uni Graz
- Pfragner Roswitha
- Reibnegger Gilbert
- Schauenstein Konrad
- Siegl Veronika
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The first human phaeochromocytoma cell line KNA was tested with regard to stimulation of dopamine biosynthesis by nicotinamide adenine dinucleotide (NADH). Differently from rat phaeochromocytoma cells - clone PC12, where NADH increased dopamine biosynthesis significantly, no stimulation in KNA cells was found. NADH is effective on speeding up the formation of the active cofactor tetrahydrobiopterin by a recycling pathway via the dihydropteridinreductase system. Another way of formation of tetrahydrobiopterin is the induction of de novo synthesis by cytokines such as interferon-gamma or by lipopolysaccharide via activation of GTP cyclohydrolase I, as shown in macrophages. Neither rat PC12 nor human KNA cells showed in vitro a stimulation of tetrahydrobiopterin de novo synthesis by interferon-gamma and/or lipopolysaccharide.
- Find related publications in this database (Keywords)
- phaeochromocytoma
- dopamine
- tetrahydrobiopterin
- interferon-gamma
- lipopolysaccharide