Medizinische Universität Graz - Research portal
Selected Publication:
Weber, T; Lu, M; Andera, L; Lahm, H; Gellert, N; Fariss, MW; Korinek, V; Sattler, W; Ucker, DS; Terman, A; Schröder, A; Erl, W; Brunk, UT; Coffey, RJ; Weber, C; Neuzil, J.
Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo.
Clin Cancer Res. 2002; 8(3):863-869
[OPEN ACCESS]
Web of Science
PubMed
FullText
Google Scholar
- Co-authors Med Uni Graz
- Sattler Wolfgang
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Abstract:
- Alpha-tocopheryl succinate (alpha-TOS), a redox-inactive analogue of vitamin E, is a strong inducer of apoptosis, whereas alpha-tocopherol (alpha-TOH) lacks apoptogenic activity (J. Neuzil et al., FASEB J., 15: 403-415, 2001). Here we investigated the possible antineoplastic activities of alpha-TOH and alpha-TOS and further explored the potential of alpha-TOS as an antitumor agent. Using nude mice with colon cancer xenografts, we found that alpha-TOH exerted modest antitumor activity and acted by inhibiting tumor cell proliferation. In contrast, alpha-TOS showed a more profound antitumor effect, at both the level of inhibition of proliferation and induction of tumor cell apoptosis. alpha-TOS was nontoxic to normal cells and tissues, triggered apoptosis in p53(-/-) and p21(Waf1/Cip1(-/-)) cancer cells, and exerted a cooperative proapoptotic activity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) due to differences in proapoptotic signaling. Finally, alpha-TOS cooperated with tumor necrosis factor-related apoptosis-inducing ligand in suppression of tumor growth in vivo. Vitamin E succinate is thus a potent and highly specific anticancer agent and/or adjuvant of considerable therapeutic potential.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antineoplastic Agents - pharmacology
- Apoptosis - drug effects
- Apoptosis Regulatory Proteins - drug effects
- Caspases - metabolism
- Colonic Neoplasms - drug therapy
- Colony-Forming Units Assay - drug therapy
- Cyclin-Dependent Kinase Inhibitor p21 - drug therapy
- Cyclins - metabolism
- Drug Synergism - metabolism
- Humans - metabolism
- Membrane Glycoproteins - metabolism
- Mice - metabolism
- Myocardial Contraction - drug effects
- Myocardium - cytology
- Neoplasm Invasiveness - cytology
- TNF-Related Apoptosis-Inducing Ligand - cytology
- Transfection - cytology
- Tumor Cells, Cultured - drug effects
- Tumor Necrosis Factor-alpha - metabolism
- Tumor Suppressor Protein p53 - metabolism
- Vitamin E - analogs and derivatives
- Xenograft Model Antitumor Assays - analogs and derivatives
- alpha-Tocopherol - pharmacology