Medizinische Universität Graz - Research portal
Selected Publication:
Smolle, J; Hofmann-Wellenhof, R; Fink-Puches, R.
Cellular invasion without cellular motility in a stochastic growth model.
Anal Cell Pathol. 1996; 10(1):37-43
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Smolle Josef
- Co-authors Med Uni Graz
- Fink-Puches Regina
- Hofmann-Wellenhof Rainer
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- Abstract:
- Invasion of a tissue by distinct cell types is common to various biological processes including embryonic development and tumour growth. Active movement is usually considered to be a prerequisite for invasiveness. Using a computer simulation program based on a stochastic cellular automata model, we provide evidence that invasive patterns may evolve in the absence of active cellular motility. Cells characterized by low proliferation, a high rate of cell loss, pronounced tumour-stroma adhesion and an expansive instead of a destructive behaviour invade the surrounding matrix, despite a complete lack of active movement. The resulting morphological patterns are similar to those obtained with motile cells. Thus invasion does not necessarily indicate the presence of motility.
- Find related publications in this database (using NLM MeSH Indexing)
- Cell Adhesion -
- Cell Death -
- Cell Division -
- Cell Movement -
- Computer Simulation -
- Models, Biological -
- Neoplasm Invasiveness -
- Neoplasms - pathology
- Software - pathology
- Stochastic Processes - pathology
- Find related publications in this database (Keywords)
- Cellular Automaton
- Invasion
- Motility
- Stochastic Growth Model